Oxygen is critical to the survival, function and fate of mammalian cells. Oxygen tension
controls cellular behavior through metabolic programming, which in turn controls tissue …

The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …

Abstract Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor essential for
cancer cell survival. The reprogramming of lipid metabolism has emerged as a hallmark of …

Purpose: To determine the antioxidant and anti-diabetic potential of a natural flavonoid,
caffeic acid in a streptozotocin-induced diabetic rat model. Methods: Experimental diabetes …

Irregularities in insulin signaling have significantly increased the risk of various cancers, yet
the precise underlying mechanisms remain unclear. Within our study, we observed that …

Although obesity is a newly considered risk factor for cancer, the mechanisms by which
adipocyte-derived metabolites accelerate cancer malignancy have yet to be elucidated. To …

Hair regeneration using hair follicle stem cells (HFSCs) and dermal papilla cells is a
promising approach for the treatment of alopecia. One of the challenges faced in this …

Hair regenerative medicine has emerged as a promising treatment strategy for severe hair
loss, such as end-stage androgenetic alopecia. Various approaches to engineering three …

Islet transplantation represents a promising therapeutic approach for diabetes management,
yet the isolation and evaluation of pancreatic islets remain challenging. This study focuses …

Dysfunctional lipid metabolism is a known cause of cancer development and progression,
yet little is known about the underlying molecular mechanisms that contribute to cancer …