Population genomics for wildlife conservation and management

PA Hohenlohe, WC Funk, OP Rajora - Molecular Ecology, 2021 - Wiley Online Library
Biodiversity is under threat worldwide. Over the past decade, the field of population
genomics has developed across nonmodel organisms, and the results of this research have …

Runs of homozygosity: windows into population history and trait architecture

FC Ceballos, PK Joshi, DW Clark, M Ramsay… - Nature Reviews …, 2018 - nature.com
Long runs of homozygosity (ROH) arise when identical haplotypes are inherited from each
parent and thus a long tract of genotypes is homozygous. Cousin marriage or inbreeding …

The long‐standing significance of genetic diversity in conservation

JA DeWoody, AM Harder, S Mathur… - Molecular …, 2021 - Wiley Online Library
Since allozymes were first used to assess genetic diversity in the 1960s and 1970s,
biologists have attempted to characterize gene pools and conserve the diversity observed in …

Understanding inbreeding depression, purging, and genetic rescue

PW Hedrick, A Garcia-Dorado - Trends in ecology & evolution, 2016 - cell.com
Inbreeding depression, the reduction of fitness caused by inbreeding, is a nearly universal
phenomenon that depends on past mutation, selection, and genetic drift. Recent estimates …

Inbreeding depression explains killer whale population dynamics

M Kardos, Y Zhang, KM Parsons, H Kang… - Nature Ecology & …, 2023 - nature.com
Understanding the factors that cause endangered populations to either grow or decline is
crucial for preserving biodiversity. Conservation efforts often address extrinsic threats, such …

Call for a paradigm shift in the genetic management of fragmented populations

K Ralls, JD Ballou, MR Dudash… - Conservation …, 2018 - Wiley Online Library
Thousands of small populations are at increased risk of extinction because genetics and
evolutionary biology are not well‐integrated into conservation planning–a major lost …

[BOOK][B] Molecular ecology

JR Freeland - 2020 - books.google.com
A fully updated guide to the increasingly prevalent use of molecular data in ecological
studies Molecular ecology is concerned with how molecular biology and population genetics …

Genetic rescue: A critique of the evidence supports maximizing genetic diversity rather than minimizing the introduction of putatively harmful genetic variation

K Ralls, P Sunnucks, RC Lacy, R Frankham - Biological Conservation, 2020 - Elsevier
Genetic rescue–ameliorating inbreeding depression and restoring genetic diversity of inbred
populations through gene flow-is valuable in wildlife conservation. Empirically validated …

Genetics and the conservation of natural populations: allozymes to genomes

FW Allendorf - 2017 - Wiley Online Library
I consider how the study of genetic variation has influenced efforts to conserve natural
populations over the last 50 years. Studies with allozymes in the 1970s provided the first …

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

A Tin, J Marten, VL Halperin Kuhns, Y Li, M Wuttke… - Nature …, 2019 - nature.com
Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via
poorly understood mechanisms. We performed a trans-ancestry genome-wide association …