Cell division facilitated by a contractile ring is an almost universal feature across all
branches of cellular life, with the notable exception of higher plants. In all organisms that use …

Cells in vivo reside within complex microenvironments composed of both biochemical and
biophysical cues. The dynamic feedback between cells and their microenvironments hinges …

Mechanical forces direct a host of cellular and tissue processes. Although much emphasis
has been placed on cell-adhesion complexes as force sensors, the forces must nevertheless …

Human carcinomas are comprised of complex mixtures of tumor cells that are known to
compete indirectly for nutrients and growth factors. Whether tumor cells could also compete …

Membrane fusion is an energy-consuming process that requires tight juxtaposition of two
lipid bilayers. Little is known about how cells overcome energy barriers to bring their …

Pulsed contractility is a widespread mode of actomyosin contractility expressed by many non-
muscle cells in which transient accumulations of F-actin and Myosin II accompany local …

To change shape, divide, form junctions, and migrate, cells reorganize their cytoskeletons in
response to changing mechanical environments [1–4]. Actin cytoskeletal elements, including …

The cellular mechanisms governing non-muscle myosin II (NM2) filament assembly are
largely unknown. Using EGFP-NM2A knock-in fibroblasts and multiple super-resolution …

Rho GTPase-based signaling networks control cellular dynamics by coordinating
protrusions and retractions in space and time. Here, we reveal a signaling network that …

Adherent cells generate forces through acto-myosin contraction to move, change shape, and
sense the mechanical properties of their environment. They are thought to maintain defined …