Renewed interest in the use of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …

This paper formulates the action of psychedelics by integrating the free-energy principle and
entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics …

BackgroundRecent open-label trials show that psychedelics, such as ayahuasca, hold
promise as fast-onset antidepressants in treatment-resistant depression. MethodsTo test the …

Psychedelics (serotonergic hallucinogens) are powerful psychoactive substances that alter
perception and mood and affect numerous cognitive processes. They are generally …

Introduction Ayahuasca is a plant-based decoction native to Amazonia, where it has a long
history of use in traditional medicine. Contemporary ritual use of ayahuasca has been …

Lysergic acid diethylamide (LSD) is the prototypical psychedelic drug, but its effects on the
human brain have never been studied before with modern neuroimaging. Here, three …

A double-blind, randomized, active placebo-controlled pilot study was conducted to examine
safety and efficacy of lysergic acid diethylamide (LSD)-assisted psychotherapy in 12 patients …

In recent years, the scientific study of meditation and psychedelic drugs has seen
remarkable developments. The increased focus on meditation in cognitive neuroscience has …

The experiences induced by psychedelics share a wide variety of subjective features,
related to the complex changes in perception and cognition induced by this class of drugs. A …

To date, pharmacological treatments for mood and anxiety disorders and for drug
dependence show limited efficacy, leaving a large number of patients suffering severe and …