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Oral drug delivery platforms for biomedical applications
Oral administration is perhaps the most commonly used and acceptable route for drug
delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …
delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …
Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application
L Chen, S Zhang, Y Duan, X Song, M Chang… - Chemical Society …, 2024 - pubs.rsc.org
The invention of silica-based bioactive glass in the late 1960s has sparked significant
interest in exploring a wide range of silicon-containing biomaterials from the macroscale to …
interest in exploring a wide range of silicon-containing biomaterials from the macroscale to …
Oral hydrogel microbeads-mediated in situ synthesis of selenoproteins for regulating intestinal immunity and microbiota
Selenoprotein plays a crucial role in immune cells and inflammatory regulation. However, as
a protein drug that is easily denatured or degraded in the acidic environment of the stomach …
a protein drug that is easily denatured or degraded in the acidic environment of the stomach …
Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy
D Zhang, D Zhong, J Ouyang, J He, Y Qi… - Nature …, 2022 - nature.com
Protecting the whole small intestine from radiation-induced intestinal injury during the
radiotherapy of abdominal or pelvic solid tumors remains an unmet clinical need. Amifostine …
radiotherapy of abdominal or pelvic solid tumors remains an unmet clinical need. Amifostine …
Oral nanomedicine: challenges and opportunities
Compared to injection administration, oral administration is free of discomfort, wound
infection, and complications and has a higher compliance rate for patients with diverse …
infection, and complications and has a higher compliance rate for patients with diverse …
An orally administered glucose-responsive polymeric complex for high-efficiency and safe delivery of insulin in mice and pigs
K Ji, X Wei, AR Kahkoska, J Zhang, Y Zhang… - Nature …, 2024 - nature.com
Contrary to current insulin formulations, endogenous insulin has direct access to the portal
vein, regulating glucose metabolism in the liver with minimal hypoglycaemia. Here we report …
vein, regulating glucose metabolism in the liver with minimal hypoglycaemia. Here we report …
Recent advances in oral and transdermal protein delivery systems
Protein and peptide drugs are predominantly administered by injection to achieve high
bioavailability, but this greatly compromises patient compliance. Oral and transdermal drug …
bioavailability, but this greatly compromises patient compliance. Oral and transdermal drug …
Bioinspired oral delivery devices
Oral administration is a widespread and convenient drug delivery approach. However, oral
delivery can be affected by the complex digestive tract environment, including irregular …
delivery can be affected by the complex digestive tract environment, including irregular …
Inorganic nanosheet-shielded probiotics: a self-adaptable oral delivery system for intestinal disease treatment
The oral delivery of probiotics is commonly adopted for intestinal disease treatments in
clinical settings; however, the probiotics suffer from a strong acidic attack in the gastric area …
clinical settings; however, the probiotics suffer from a strong acidic attack in the gastric area …
Oral insulin delivery: Barriers, strategies, and formulation approaches: A comprehensive review
Diabetes Mellitus is characterized by a hyperglycemic condition which can either be caused
by the destruction of the beta cells or by the resistance developed against insulin in the cells …
by the destruction of the beta cells or by the resistance developed against insulin in the cells …