Oral drug delivery platforms for biomedical applications

J Ouyang, Z Zhang, B Deng, J Liu, L Wang, H Liu… - Materials Today, 2023 - Elsevier
Oral administration is perhaps the most commonly used and acceptable route for drug
delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

L Chen, S Zhang, Y Duan, X Song, M Chang… - Chemical Society …, 2024 - pubs.rsc.org
The invention of silica-based bioactive glass in the late 1960s has sparked significant
interest in exploring a wide range of silicon-containing biomaterials from the macroscale to …

Oral hydrogel microbeads-mediated in situ synthesis of selenoproteins for regulating intestinal immunity and microbiota

J Ouyang, B Deng, B Zou, Y Li, Q Bu… - Journal of the …, 2023 - ACS Publications
Selenoprotein plays a crucial role in immune cells and inflammatory regulation. However, as
a protein drug that is easily denatured or degraded in the acidic environment of the stomach …

Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy

D Zhang, D Zhong, J Ouyang, J He, Y Qi… - Nature …, 2022 - nature.com
Protecting the whole small intestine from radiation-induced intestinal injury during the
radiotherapy of abdominal or pelvic solid tumors remains an unmet clinical need. Amifostine …

Oral nanomedicine: challenges and opportunities

B Deng, S Liu, Y Wang, B Ali, N Kong, T **e… - Advanced …, 2024 - Wiley Online Library
Compared to injection administration, oral administration is free of discomfort, wound
infection, and complications and has a higher compliance rate for patients with diverse …

An orally administered glucose-responsive polymeric complex for high-efficiency and safe delivery of insulin in mice and pigs

K Ji, X Wei, AR Kahkoska, J Zhang, Y Zhang… - Nature …, 2024 - nature.com
Contrary to current insulin formulations, endogenous insulin has direct access to the portal
vein, regulating glucose metabolism in the liver with minimal hypoglycaemia. Here we report …

Recent advances in oral and transdermal protein delivery systems

Y Yang, R Zhou, Y Wang, Y Zhang, J Yu… - Angewandte …, 2023 - Wiley Online Library
Protein and peptide drugs are predominantly administered by injection to achieve high
bioavailability, but this greatly compromises patient compliance. Oral and transdermal drug …

Bioinspired oral delivery devices

X Zhang, G Chen, H Zhang, L Shang… - Nature Reviews …, 2023 - nature.com
Oral administration is a widespread and convenient drug delivery approach. However, oral
delivery can be affected by the complex digestive tract environment, including irregular …

Inorganic nanosheet-shielded probiotics: a self-adaptable oral delivery system for intestinal disease treatment

YX Zhu, Y You, Z Chen, D Xu, W Yue, X Ma, J Jiang… - Nano Letters, 2023 - ACS Publications
The oral delivery of probiotics is commonly adopted for intestinal disease treatments in
clinical settings; however, the probiotics suffer from a strong acidic attack in the gastric area …

Oral insulin delivery: Barriers, strategies, and formulation approaches: A comprehensive review

SS Shetty, P Halagali, AP Johnson… - International Journal of …, 2023 - Elsevier
Diabetes Mellitus is characterized by a hyperglycemic condition which can either be caused
by the destruction of the beta cells or by the resistance developed against insulin in the cells …