Defensins are small, multifunctional cationic peptides. They typically contain six conserved
cysteines whose three intramolecular disulfides stabilize a largely β‐sheet structure. This …

Defensins are antimicrobial and cytotoxic peptides that contain 29-35 amino acid residues,
including six invariant cysteines whose intramolecular disulfide bonds cyclize and stabilize …

Cystic fibrosis (CF) is a life-shortening disease caused by mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene. Although bacterial lung infection and …

We report the isolation and characterization of a novel human peptide with antimicrobial
activity, termed LEAP-1 (liver-expressed antimicrobial peptide). Using a mass spectrometric …

The growing public health problem of infections caused by multiresistant Gram-positive
bacteria, in particularStaphylococcus aureus, prompted us to screen human epithelia for …

With the rise in prevalence of antibioticresistant bacteria, honey is increasingly valued for its
antibacterial activity. To characterize all bactericidal factors in a medical‐grade honey, we …

Defensins are antimicrobial peptides that contribute broadly to innate immunity, including
protection of mucosal tissues. Human α-defensin (HD) 6 is highly expressed by secretory …

Platelets share structural and functional similarities with granulocytes known to participate in
antimicrobial host defense. To evaluate the potential antimicrobial activities of platelet …

Human epithelia are permanently challenged by bacteria and fungi, including commensal
and pathogenic microbiota,. In the gut, the fraction of strict anaerobes increases from …

Cathelicidin LL-37 is one of the few human bactericidal peptides with potent
antistaphylococcal activity. In this study we examined the susceptibility of LL-37 to proteolytic …