Adaptive optics for high-resolution imaging

KM Hampson, R Turcotte, DT Miller… - Nature Reviews …, 2021 - nature.com
Adaptive optics (AO) is a technique that corrects for optical aberrations. It was originally
proposed to correct for the blurring effect of atmospheric turbulence on images in ground …

Choriocapillaris: fundamentals and advancements

R Lejoyeux, J Benillouche, J Ong, MH Errera… - Progress in Retinal and …, 2022 - Elsevier
The choriocapillaris is the innermost structure of the choroid that directly nourishes the
retinal pigment epithelium and photoreceptors. This article provides an overview of its …

Twenty-five years of clinical applications using adaptive optics ophthalmoscopy

JIW Morgan, TYP Chui, K Grieve - Biomedical optics express, 2022 - opg.optica.org
Twenty-five years ago, adaptive optics (AO) was combined with fundus photography,
thereby initiating a new era in the field of ophthalmic imaging. Since that time, clinical …

Ultrahigh-speed multimodal adaptive optics system for microscopic structural and functional imaging of the human retina

Z Liu, F Zhang, K Zucca, A Agrawal… - Biomedical optics …, 2022 - opg.optica.org
We describe the design and performance of a multimodal and multifunctional adaptive
optics (AO) system that combines scanning laser ophthalmoscopy (SLO) and optical …

Integrating adaptive optics-SLO and OCT for multimodal visualization of the human retinal pigment epithelial mosaic

AJ Bower, T Liu, N Aguilera, J Li, J Liu, R Lu… - Biomedical optics …, 2021 - opg.optica.org
In vivo imaging of human retinal pigment epithelial (RPE) cells has been demonstrated
through multiple adaptive optics (AO)-based modalities. However, whether consistent and …

Widespread subclinical cellular changes revealed across a neural-epithelial-vascular complex in choroideremia using adaptive optics

N Aguilera, T Liu, AJ Bower, J Li, S Abouassali… - Communications …, 2022 - nature.com
Choroideremia is an X-linked, blinding retinal degeneration with progressive loss of
photoreceptors, retinal pigment epithelial (RPE) cells, and choriocapillaris. To study the …

In-vivo sub-diffraction adaptive optics imaging of photoreceptors in the human eye with annular pupil illumination and sub-Airy detection

R Lu, N Aguilera, T Liu, J Liu, JP Giannini, J Li… - Optica, 2021 - opg.optica.org
Adaptive optics scanning light ophthalmoscopy (AOSLO) allows non-invasive visualization
of the living human eye at the microscopic scale; but even with correction of the ocular …

Current choroidal imaging findings in central serous chorioretinopathy

G Nkrumah, DS Maltsev, PEA Manuel, MA Rasheed… - Vision, 2020 - mdpi.com
Background: Central serous chorioretinopathy (CSCR) is a chorioretinal disease affecting
mostly middle age males. It is marked by the serous detachment of the neurosensory layer at …

Active cell appearance model induced generative adversarial networks for annotation-efficient cell segmentation and identification on adaptive optics retinal images

J Liu, C Shen, N Aguilera, C Cukras… - IEEE transactions on …, 2021 - ieeexplore.ieee.org
Data annotation is a fundamental precursor for establishing large training sets to effectively
apply deep learning methods to medical image analysis. For cell segmentation, obtaining …

New developments in angiography for the diagnosis and management of diabetic retinopathy

D Mustafi, SS Saraf, Q Shang, LCO de Koo - Diabetes Research and …, 2020 - Elsevier
The most common microvascular complication of diabetes is diabetic retinopathy, the
leading cause of blindness in adults of working age. Our understanding of the vascular …