Animal models are essential tools for addressing fundamental scientific questions about
skeletal diseases and for the development of new therapeutic approaches. Traditionally …

Many genes are members of large families that have arisen during evolution through gene
duplication events. Our increasing understanding of gene organization at the scale of whole …

Over the last several decades zebrafish (Danio rerio) has become a major model organism
for the study of vertebrate development and physiology. Given this, it may be surprising how …

The role of Anti-Müllerian hormone (Amh) during gonad development has been studied
extensively in mammals, but is less well understood in other vertebrates. In male …

The formation of the face and skull involves a complex series of developmental events
mediated by cells derived from the neural crest, endoderm, mesoderm, and ectoderm …

Zebrafish combine the relevance of a vertebrate with the scalability of an invertebrate. They
can live in 96-well plate format and readily absorb chemicals from the water. These features …

Half of all vertebrate species are teleost fish. What accounts for this explosion of
biodiversity? Recent evidence and advances in evolutionary theory suggest that genomic …

The zebrafish, Danio rerio, has come to the forefront of biomedical research as a powerful
model for the study of development, neurobiology, and genetics of humans. In recent years …

Background: The morphogenetic events of early vertebrate development generally involve
the combined actions of several populations of cells, each engaged in a distinct behavior …

Understanding how developmental systems evolve after genome amplification is important
for discerning the origins of vertebrate novelties, including neural crest, placodes, cartilage …