Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate
significantly from the average genomic pattern by being GC-rich, CpG-rich, and …

DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has
become clear that the DNA and histone lysine methylation systems are highly interrelated …

Histone side chains are post-translationally modified at multiple sites, including at Lys36 on
histone H3 (H3K36). Several enzymes from yeast and humans, including the …

Recent studies of transcription have revealed a level of complexity not previously
appreciated even a few years ago, both in the intricate use of post-initiation control and the …

Histone modifications not only play important roles in regulating chromatin structure and
nuclear processes but also can be passed to daughter cells as epigenetic marks …

SET domain-containing proteins belong to a group of enzymes named after a common
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …

Set2-mediated methylation of histone H3 Lys36 (H3K36) is a mark associated with the
coding sequences of actively transcribed genes, but it has a negative role during …

Vertebrate DNA can be chemically modified by methylation of the 5 position of the cytosine
base in the context of CpG dinucleotides. This modification creates a binding site for MBD …

In higher eukaryotes, up to 70% of genes have high levels of nonmethylated
cytosine/guanine base pairs (CpGs) surrounding promoters and gene regulatory units …

The NSD (nuclear receptor SET domain-containing) family of histone lysine
methyltransferases is a critical participant in chromatin integrity as evidenced by the number …