Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CLpro and PLpro), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin …

C Mouffouk, S Mouffouk, S Mouffouk… - European journal of …, 2021 - Elsevier
The novel coronavirus outbreak (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) represents the actual greatest global public health crisis. The …

Cardiotoxicity of some pesticides and their amelioration

Y El-Nahhal, I El-Nahhal - Environmental Science and Pollution Research, 2021 - Springer
Pesticides are used to control pests that harm plants, animals, and humans. Their
application results in the contamination of the food and water systems. Pesticides may cause …

Formulation and characterization of metformin-loaded ethosomes for topical application to experimentally induced skin cancer in mice

IA Mousa, TM Hammady, S Gad, SA Zaitone… - Pharmaceuticals, 2022 - mdpi.com
To achieve the best treatment of skin cancer, drug penetration inside the deepest layers of
the skin is an important scientific interest. We designed an ethosome formulation that serves …

Pomegranate juice diminishes the mitochondria-dependent cell death and NF-kB signaling pathway induced by copper oxide nanoparticles on liver and kidneys of …

EI Hassanen, AF Tohamy, MY Issa… - International journal …, 2019 - Taylor & Francis
Background Pomegranate (Punica granatum L) has been used since ancient times in the
traditional medicine of several cultures, particularly in the Middle East. It is an essential …

Atrazine exposure triggers common carp neutrophil apoptosis via the CYP450s/ROS pathway

S Wang, Q Zhang, S Zheng, M Chen, F Zhao… - Fish & shellfish …, 2019 - Elsevier
Due to the excessive pursuit of crop yields and the abuse of herbicides, water pollution
caused by atrazine (ATR) has become one of the most severe environmental issues …

Exogenous L-carnitine administration ameliorates the adverse effects of heat stress on testicular hemodynamics, echotexture, and total antioxidant capacity in rams

HR El-Sherbiny, AS El-Shalofy, H Samir - Frontiers in veterinary …, 2022 - frontiersin.org
Heat stress (HS) diminishes the testicular antioxidant defense systems, which adversely
affect the testicular blood perfusion. Improving the testicular hemodynamics during HS …

Rosmarinic acid attenuates chromium‐induced hepatic and renal oxidative damage and DNA damage in rats

AA Khalaf, EI Hassanen, MA Ibrahim… - … of biochemical and …, 2020 - Wiley Online Library
Abstract Hexavelant chromium (Cr (V1)) is a widely distributed environmental pollutant
inducing damage in different organs of human and animals. The current study was designed …

Silk fibroin microneedles loaded with epigallocatechin gallate mitigate atrazine-induced testicular toxicity

C Fang, Y Li, G He, RY Gan, F Luo, L Lei, X Hou… - Journal of Hazardous …, 2024 - Elsevier
Atrazine (ATZ), a commonly used herbicide, disrupts male endocrine systems, impacting
reproductive health. Epigallocatechin gallate (EGCG) possesses potent antioxidant …

Atrazine toxicity: the possible role of natural products for effective treatment

S Das, H Sakr, I Al-Huseini, R Jetti, S Al-Qasmi… - Plants, 2023 - mdpi.com
There are various herbicides which were used in the agriculture industry. Atrazine (ATZ) is a
chlorinated triazine herbicide that consists of a ring structure, known as the triazine ring …

Pharmacological activity of flavonoid quercetin and its therapeutic potential in testicular injury

X Zhang, Y Tang, G Lu, J Gu - Nutrients, 2023 - mdpi.com
Quercetin is a natural flavonoid widely found in natural fruits and vegetables. Recent studies
have shown that quercetin mediates multiple beneficial effects in a variety of organ damage …