[HTML][HTML] The role of m6A RNA methylation in cancer
T Sun, R Wu, L Ming - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Abstract N6-methyladenosine (m6A), the most abundant internal modification of RNA in
eukaryotic cells, has gained increasing attention in recent years. The m6A modification …
eukaryotic cells, has gained increasing attention in recent years. The m6A modification …
FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
FTO-Dependent N6-Methyladenosine Regulates Cardiac Function During Remodeling and Repair
Background: Despite its functional importance in various fundamental bioprocesses, studies
of N6-methyladenosine (m6A) in the heart are lacking. Here, we show that the FTO (fat mass …
of N6-methyladenosine (m6A) in the heart are lacking. Here, we show that the FTO (fat mass …
N6-methyladenosine-mediated gene regulation and therapeutic implications
Abstract N6-methyladenosine (m 6 A) RNA methylation is the most abundant form of mRNA
modification in eukaryotes and is at the front line of biological and biomedical research. This …
modification in eukaryotes and is at the front line of biological and biomedical research. This …
METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial–mesenchymal transition of renal tubular cells in diabetic kidney disease
Z Xu, K Jia, H Wang, F Gao, S Zhao, F Li, J Hao - Cell death & disease, 2021 - nature.com
Abstract Histone deacetylase 5 (HDAC5) belongs to class II HDAC subfamily and is reported
to be increased in the kidneys of diabetic patients and animals. However, little is known …
to be increased in the kidneys of diabetic patients and animals. However, little is known …
The biological function of m6A demethylase ALKBH5 and its role in human disease
J Wang, J Wang, Q Gu, Y Ma, Y Yang, J Zhu… - Cancer cell …, 2020 - Springer
Abstract Human AlkB homolog H5 (ALKBH5) is a primary m6A demethylase, which is
dysregulated and acts as a biological and pharmacological role in human cancers or non …
dysregulated and acts as a biological and pharmacological role in human cancers or non …
Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5
Y Huang, J Yan, Q Li, J Li, S Gong, H Zhou… - Nucleic acids …, 2015 - academic.oup.com
Two human demethylases, the fat mass and obesity-associated (FTO) enzyme and ALKBH5,
oxidatively demethylate abundant N 6-methyladenosine (m6A) residues in mRNA …
oxidatively demethylate abundant N 6-methyladenosine (m6A) residues in mRNA …
The AlkB family of Fe (II)/α-ketoglutarate-dependent dioxygenases: repairing nucleic acid alkylation damage and beyond
The AlkB family of Fe (II)-and α-ketoglutarate-dependent dioxygenases is a class of
ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases …
ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases …
The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA
J Li, Y Han, H Zhang, Z Qian, W Jia, Y Gao… - Biochemical and …, 2019 - Elsevier
Lung cancer is one of the leading causes of cancer-related death in developed countries.
Despite decades of intensive efforts to comate this malignant disease, the prognosis of lung …
Despite decades of intensive efforts to comate this malignant disease, the prognosis of lung …
m6A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin
D Liang, WJ Lin, M Ren, J Qiu, C Yang, X Wang, N Li… - Autophagy, 2022 - Taylor & Francis
Dysregulation of macroautophagy/autophagy contributes to the delay of wound healing in
diabetic skin. N6-methyladenosine (m6A) RNA modification is known to play a critical role in …
diabetic skin. N6-methyladenosine (m6A) RNA modification is known to play a critical role in …