CNS small vessel disease: a clinical review

RJ Cannistraro, M Badi, BH Eidelman, DW Dickson… - Neurology, 2019 - AAN Enterprises
CNS small vessel disease (CSVD) causes 25% of strokes and contributes to 45% of
dementia cases. Prevalence increases with age, affecting about 5% of people aged 50 …

Gait disorders in adults and the elderly: A clinical guide

W Pirker, R Katzenschlager - Wiener Klinische Wochenschrift, 2017 - Springer
Human gait depends on a complex interplay of major parts of the nervous, musculoskeletal
and cardiorespiratory systems. The individual gait pattern is influenced by age, personality …

Cerebral small vessel disease

Q Li, Y Yang, C Reis, T Tao, W Li, X Li… - Cell …, 2018 - journals.sagepub.com
Cerebral small vessel disease (CSVD) is composed of several diseases affecting the small
arteries, arterioles, venules, and capillaries of the brain, and refers to several pathological …

What are white matter hyperintensities made of? Relevance to vascular cognitive impairment

JM Wardlaw, MC Valdés Hernández… - Journal of the …, 2015 - Am Heart Assoc
White matter hyperintensities (WMH) of presumed vascular origin, also referred to as
leukoaraiosis, are a very common finding on brain magnetic resonance imaging (MRI) or …

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

JM Wardlaw, EE Smith, GJ Biessels… - The Lancet …, 2013 - thelancet.com
Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen
on neuroimaging include recent small subcortical infarcts, lacunes, white matter …

Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging

JM Wardlaw, C Smith, M Dichgans - The Lancet Neurology, 2013 - thelancet.com
The term cerebral small vessel disease (SVD) describes a range of neuroimaging,
pathological, and associated clinical features. Clinical features range from none, to discrete …

Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats

RM Rajani, S Quick, SR Ruigrok, D Graham… - Science translational …, 2018 - science.org
Dementia is a major social and economic problem for our aging population. One of the most
common of dementia in the elderly is cerebral small vessel disease (SVD). Magnetic …

Neuroimaging of mobility in aging: a targeted review

R Holtzer, N Epstein, JR Mahoney… - … Series A: Biomedical …, 2014 - academic.oup.com
Background. The relationship between mobility and cognition in aging is well established,
but the relationship between mobility and the structure and function of the aging brain is …

Cerebral small vessel disease: Pathological mechanisms and potential therapeutic targets

Y Gao, D Li, J Lin, AM Thomas, J Miao… - Frontiers in aging …, 2022 - frontiersin.org
Cerebral small vessel disease (CSVD) represents a diverse cluster of cerebrovascular
diseases primarily affecting small arteries, capillaries, arterioles and venules. The diagnosis …

Moving forward on gait measurement: toward a more refined approach

S Lord, B Galna, L Rochester - Movement Disorders, 2013 - Wiley Online Library
Gait is emerging as a powerful measurement tool in neurodegenerative disorders to identify
markers of incipient pathology, inform diagnostic algorithms and disease progression, and …