Treatment of infectious diseases becomes more challenging with each passing year. This is
especially true for infections caused by the opportunistic pathogen Pseudomonas …

In Gram-negative bacteria, the insertion sequence IS 26 is highly active in disseminating
antibiotic resistance genes. IS 26 can recruit a gene or group of genes into the mobile gene …

Macrolide resistance mechanisms can be target-based with a change in a 23S ribosomal
RNA (rRNA) residue or a mutation in ribosomal protein L4 or L22 affecting the ribosome's …

SUMMARY “Common regions”(CRs), such as Orf513, are being increasingly linked to mega-
antibiotic-resistant regions. While their overall nucleotide sequences show little identity to …

This study aimed to reveal how antibiotic resistance genes (ARGs) and their horizontal and
vertical transfer-related items (mobilome and bacterial hosts) respond to the transformation …

The integron is a powerful system which, by capturing, stockpiling, and rearranging new
functions carried by gene encoding cassettes, confers upon bacteria a rapid adaptation …

Exogenously acquired 16S rRNA methyltransferase (16S-RMTase) genes responsible for a
very high level of resistance against various aminoglycosides have been widely distributed …

Soil bacteria may contain antibiotic resistance genes responsible for different mechanisms
that permit them to overcome the natural antibiotics present in the environment. This gene …

We have isolated a multiple-aminoglycoside-resistant Escherichia coli strain, strain ARS3,
and have been the first to identify a novel plasmid-mediated 16S rRNA methyltransferase …

ABSTRACT A total of 49 unique clinical isolates of multidrug-resistant (MDR) Acinetobacter
baumannii identified at a tertiary medical center in Pittsburgh, Pennsylvania, between …