The histone-like nucleoid structuring (H-NS) protein is a major component of the folded
chromosome in Escherichia coli and related bacteria. Functions attributed to H-NS include …

Highlights•H-NS and other nucleoid-associated proteins can silence expression of
horizontally-acquired genes.•Transcriptional silencing is countered by other DNA-binding …

The bacterial H-NS protein silences expression from sequences with higher AT-content than
the host genome and is believed to buffer the fitness consequences associated with foreign …

Colonization of the intestinal epithelium by enterohaemorrhagic Escherichia coli (EHEC) is
characterized by an attaching and effacing (A/E) histopathology. The locus of enterocyte …

Type III secretion (T3S) systems enable the injection of bacterial proteins through membrane
barriers into host cells, either from outside the host cell or from within a vacuole. This system …

The H-NS family of DNA-binding proteins is the subject of intense study due to its important
roles in the regulation of horizontally acquired genes critical for virulence, antibiotic …

Ler, encoded by the locus of enterocyte effacement (LEE) of attaching and effacing (A/E)
pathogens, induces the expression of LEE genes by counteracting the silencing exerted by …

Enterohaemorrhagic E scherichia coli (EHEC) causes bloody diarrhoea and other severe
symptoms such as haemorrhagic uraemic syndrome. The expression of virulence genes on …

Ler, a member of the H-NS protein family, is the master regulator of the LEE pathogenicity
island in virulent Escherichia coli strains. Here, we determined the structure of a complex …

The lifecycle of most microbial pathogens can be divided into two states: existence outside
and inside their hosts. The sudden temperature upshift experienced upon entry from …