Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than
700 species, have always been one of the focuses for new drug discovery. These venomous …

Venom and poison peptides are powerful biological weapons and have proven immense
pharmacological potential because of their high binding affinity to a wide range of molecular …

The diversity of venomous organisms and the toxins they produce have been increasingly
investigated, but taxonomic bias remains important. Neogastropods, a group of marine …

The intense pain induced by scorpion sting is a frequent clinical manifestation. To date,
there is no established protocol with significant efficacy to alleviate the pain induced by …

Several analgesic α-conotoxins have been isolated from marine cone snails. Structural
modification of native peptides has provided potent and selective analogues for two of its …

The venom of each Conus species consists of a diverse array of neurophysiologically active
peptides, which are mostly unique to the examined species. In this study, we performed high …

ABSTRACT Background: The venom of Phoneutria nigriventer spider is a source of
numerous bioactive substances, including some toxins active in insects. An example is …

Analgesic therapy is based on the sequential treatment of pain, in which opioids are drugs of
last resource and known to be highly effective, but are also responsible for undesirable side …

Pain is a major symptom of many diseases and results in enormous pressures on human
body or society. Currently, clinically used analgesic drugs, including opioids and …

Cone snails are biomedically important sources of peptide drugs, but it is not known whether
snail-associated bacteria affect venom chemistry. To begin to answer this question, we …