Tumors display reprogrammed metabolic activities that promote cancer progression. We
currently possess a limited understanding of the processes governing tumor metabolism in …

Kidney cancer is not a single disease but represents several distinct types of cancer that
have defining histologies and genetic alterations and that follow different clinical courses …

Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound
transcription factors that activate genes encoding enzymes required for synthesis of …

Clear cell renal cell carcinoma (ccRCC) is the most common form of human kidney cancer.
Histological and molecular analyses suggest that ccRCCs have significantly altered …

Reprogrammed metabolism supports tumor growth and provides a potential source of
therapeutic targets and disease biomarkers. Mass spectrometry-based metabolomics has …

Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell
carcinoma (RCC). Here, we analyzed the metabolism of patient-derived xenografts …

Tumor cell phenotypes and anti-tumor immune responses are shaped by local metabolite
availability, but intratumoral metabolite heterogeneity (IMH) and its phenotypic …

Fibroblast activation is an accompanying feature of solid tumor progression, resembling a
conserved host response to tissue damage. Cancer-associated fibroblasts (CAFs) comprise …

Metabolic adaptations are emerging hallmarks of cancer progression and cellular
transformation. Clear cell renal cell carcinoma (ccRCC) is a metabolic disease defined …

Renal tumors encompass a broad disease spectrum, from benign and indolent lesions to
aggressive and invasive malignancies. Imaging plays a critical role in the management of …