Glaucoma: From pathogenic mechanisms to retinal glial cell response to damage

JA Fernández-Albarral, AI Ramírez… - Frontiers in Cellular …, 2024 - frontiersin.org
Glaucoma is a neurodegenerative disease of the retina characterized by the irreversible loss
of retinal ganglion cells (RGCs) leading to visual loss. Degeneration of RGCs and loss of …

Sustained release glaucoma therapies: Novel modalities for overcoming key treatment barriers associated with topical medications

A Belamkar, A Harris, R Zukerman, B Siesky… - Annals of …, 2022 - Taylor & Francis
Glaucoma is a progressive optic neuropathy and a leading cause of irreversible blindness.
The disease has conventionally been characterized by an elevated intraocular pressure …

Ocular blood flow as a clinical observation: Value, limitations and data analysis

A Harris, G Guidoboni, B Siesky, S Mathew… - Progress in retinal and …, 2020 - Elsevier
Alterations in ocular blood flow have been identified as important risk factors for the onset
and progression of numerous diseases of the eye. In particular, several population-based …

[HTML][HTML] Oxidative stress and the role of NADPH oxidase in glaucoma

JC Fan Gaskin, MH Shah, EC Chan - Antioxidants, 2021 - mdpi.com
Glaucoma is characterised by loss of retinal ganglion cells, and their axons and many
pathophysiological processes are postulated to be involved. It is increasingly understood …

Therapeutic ophthalmic lenses: a review

N Toffoletto, B Saramago, AP Serro - Pharmaceutics, 2020 - mdpi.com
An increasing incidence of eye diseases has been registered in the last decades in
developed countries due to the ageing of population, changes in lifestyle, environmental …

Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities

KA Fernandes, JM Harder, PA Williams… - Experimental eye …, 2015 - Elsevier
While all forms of glaucoma are characterized by a specific pattern of retinal ganglion cell
death, they are clinically divided into several distinct subclasses, including normal tension …

Blood flow mechanics and oxygen transport and delivery in the retinal microcirculation: multiscale mathematical modeling and numerical simulation

P Causin, G Guidoboni, F Malgaroli, R Sacco… - … and modeling in …, 2016 - Springer
The scientific community continues to accrue evidence that blood flow alterations and
ischemic conditions in the retina play an important role in the pathogenesis of ocular …

The role of endogenous neuroprotective mechanisms in the prevention of retinal ganglion cells degeneration

M Pietrucha-Dutczak, M Amadio, S Govoni… - Frontiers in …, 2018 - frontiersin.org
Retinal neurons are not able to undergo spontaneous regeneration in response to damage.
A variety of stressors, ie, UV radiation, high temperature, ischemia, allergens, and others …

Systemic diseases and their association with open-angle glaucoma in the population of Stockholm

P Wändell, AC Carlsson, G Ljunggren - International ophthalmology, 2022 - Springer
Objective We aimed to study open-angle glaucoma in association with somatic
comorbidities in the total population of adults in Region Stockholm. Methods The study …

A time window for rescuing dying retinal ganglion cells

W You, K Knoops, I Boesten, TTJM Berendschot… - Cell Communication and …, 2024 - Springer
Background Retinal ganglion cell (RGC) degeneration and death cause vision loss in
patients with glaucoma. Regulated cell death, once initiated, is generally considered to be …