Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Background Puberty, a complex biologic process involving sexual development, accelerated
linear growth, and adrenal maturation, is initiated when gonadotropin-releasing hormone …

Natural peptides displaying agonist activity on the orphan G protein-coupled receptor
GPR54 were isolated from human placenta. These 54-, 14,-and 13-amino acid peptides …

Metastasis is a major cause of death in cancer patients and involves a multistep process
including detachment of cancer cells from a primary cancer, invasion of surrounding tissue …

We have recently described a molecular gatekeeper of the hypothalamic-pituitary-gonadal
axis with the observation that G protein-coupled receptor 54 (GPR54) is required in mice …

Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

A novel human G protein-coupled receptor named AXOR12, exhibiting 81% homology to the
rat orphan receptor GPR54, was cloned from a human brain cDNA library. Heterologous …

It is now widely accepted that cancer is attributed to the accumulation of genetic alterations
in cells. Thus, to understand the molecular mechanisms of cancer metastasis, it is …

The G protein-coupled receptor GPR54 (AXOR12, OT7T175) is central to acquisition of
reproductive competency in mammals. Peptide ligands (kisspeptins) for this receptor are …