Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …

Over 17 and 160 types of chemical modifications have been identified in DNA and RNA,
respectively. The interest in understanding the various biological functions of DNA and RNA …

Bisulfite sequencing has been the gold standard for map** DNA modifications including 5-
methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) for decades,,–. However, this …

Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

Bisulfite sequencing is a powerful technique to detect 5-methylcytosine in DNA that has
immensely contributed to our understanding of epigenetic regulation in plants and animals …

The importance of eukaryotic DNA methylation [5-methylcytosine (5mC)] in transcriptional
regulation and development was first suggested almost 40 years ago. However, the …

The discovery of epigenetic bases has revolutionised the understanding of disease and
development. Among the most studied epigenetic marks are cytosines covalently modified at …

Chemical modifications of DNA have been recognized as key epigenetic mechanisms for
maintenance of the cellular state and memory. Such DNA modifications include canonical 5 …

Histone post-translational modifications (HPTMs), as one of the core mechanisms of
epigenetic regulation, are garnering increasing attention due to their close association with …