Chemistries of bifunctional PROTAC degraders
C Cao, M He, L Wang, Y He, Y Rao - Chemical Society Reviews, 2022 - pubs.rsc.org
Proteolysis targeting chimeras (PROTACs) technology is a novel and promising therapeutic
strategy using small molecules to induce ubiquitin-dependent degradation of proteins. It has …
strategy using small molecules to induce ubiquitin-dependent degradation of proteins. It has …
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)
M He, C Cao, Z Ni, Y Liu, P Song, S Hao, Y He… - … and Targeted Therapy, 2022 - nature.com
Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …
New insights into the molecular and cellular functions of poly (ADP-ribose) and PARPs
Abstract Poly (ADP-ribose) polymerases (PARPs) are enzymes that transfer ADP-ribose
groups to target proteins and thereby affect various nuclear and cytoplasmic processes. The …
groups to target proteins and thereby affect various nuclear and cytoplasmic processes. The …
ADP‐ribosyltransferases, an update on function and nomenclature
ADP‐ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad
functions, including roles in stress responses elicited, for example, by DNA damage and …
functions, including roles in stress responses elicited, for example, by DNA damage and …
Poly (ADP-ribosyl) ation by PARP1: reaction mechanism and regulatory proteins
EE Alemasova, OI Lavrik - Nucleic acids research, 2019 - academic.oup.com
Abstract Poly (ADP-ribosyl) ation (PARylation) is posttranslational modification of proteins by
linear or branched chains of ADP-ribose units, originating from NAD+. The central enzyme …
linear or branched chains of ADP-ribose units, originating from NAD+. The central enzyme …
PARP inhibition: PARP1 and beyond
Recent findings have thrust poly (ADP-ribose) polymerases (PARPs) into the limelight as
potential chemotherapeutic targets. To provide a framework for understanding these recent …
potential chemotherapeutic targets. To provide a framework for understanding these recent …
ADP-ribosylation from molecular mechanisms to therapeutic implications
ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets
The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure,
transcription, and genomic integrity, plays key roles in a wide variety of processes in the …
transcription, and genomic integrity, plays key roles in a wide variety of processes in the …
Toward a unified nomenclature for mammalian ADP-ribosyltransferases
ADP-ribosylation is a post-translational modification of proteins catalyzed by ADP-
ribosyltransferases. It comprises the transfer of the ADP-ribose moiety from NAD+ to specific …
ribosyltransferases. It comprises the transfer of the ADP-ribose moiety from NAD+ to specific …
DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates
Ubiquitylation had been considered limited to protein lysine residues, but other substrates
have recently emerged. Here, we show that DELTEX E3 ligases specifically target the 3 …
have recently emerged. Here, we show that DELTEX E3 ligases specifically target the 3 …