Chronic insult and persistent injury can cause liver inflammation, fibrosis, and
carcinogenesis; it can also be associated with metabolic disorders. Identification of critical …

The predominant kind of liver cancer is hepatocellular carcinoma (HCC) that its treatment
have been troublesome difficulties for physicians due to aggressive behavior of tumor cells …

Nonalcoholic steatohepatitis (NASH) is a common clinical condition that can lead to
advanced liver diseases. Lack of effective pharmacotherapies for NASH is largely …

Background Galectins are beta-galactose specific binding proteins. In human cancers,
including hepatocellular carcinoma (HCC), galectin-1 (Gal-1) is often found to be …

Patient‐derived cancer organoids (PDOs) hold considerable promise for personalizing
therapy selection and improving patient outcomes. However, it is challenging to generate …

Formation of the premetastatic niche is triggered by primary tumors and contributes to
cancer metastasis. Evidence indicating the roles of macrophages in metastatic niche …

Background Hepatocellular carcinoma (HCC) is the most common tumors in the worldwide,
it develops resistance to radiotherapy during treatment, understanding the regulatory …

Abstract Ethnopharmacological relevance Litchi chinensis Sonn.(Litchi) seed, a traditional
Chinese medicine, is habitually used in the clinical treatment of prostate cancer (PCa) …

Genetic aberrations driving pro-oncogenic and pro-metastatic activity remain an elusive
target in the quest of precision oncology. To identify such drivers, we use an animal model of …

Background. PANoptosis has been a research hotspot, but the role of PANoptosis in
hepatocellular carcinoma (HCC) remains widely unknown. Drug resistance and low …