Signal transducer and activator of transcription (STAT) proteins are latent transcription
factors that reside in the cytoplasm of several types of cells. In canonical signaling, upon …

The protein inhibitor of activated STAT (PIAS) family of proteins has been proposed to
regulate the activity of many transcription factors, including signal transducer and activator of …

Plants sense phosphate (Pi) deficiency and initiate signaling that controls adaptive
responses necessary for Pi acquisition. Herein, evidence establishes that AtSIZ1 is a plant …

The interactions and functions of protein inhibitors of activated STAT (PIAS) proteins are not
restricted to the signal transducers and activators of transcription (STATs), but PIAS1,-2,-3 …

Cytokines activate multiple signal transduction pathways to regulate gene expression.
STATs and NF-kB are two important families of transcription factors activated by cytokines …

Glioblastoma is the most common and severe primary brain tumor in adults. Its aggressive
and infiltrative nature renders the current therapeutics of surgical resection, radiation, and …

The protein inhibitor of activated STAT1 (PIAS1) is an E3 SUMO ligase that plays important
roles in various cellular pathways. Increasing evidence shows that PIAS1 is overexpressed …

Transcriptional activity of signal-dependent transcription factors, including nuclear receptors,
relies on interacting co-regulator proteins, many of which possess protein-modifying activity …

STAT3 mediated signaling pathways can be inhibited by PIAS3 (protein inhibitor of activated
STAT3), which was recently found to regulate protein stability and function by its SUMO …

Protein inhibitor of activated STAT (PIAS) proteins are activation-suppressing proteins for
signal transducer and activator of transcription (STAT), which involves gene transcriptional …