Inactivated recombinant influenza vaccine: the promising direction for the next generation of influenza vaccine

H Shi, TM Ross - Expert Review of Vaccines, 2024 - Taylor & Francis
Introduction Vaccination is the most effective method to control the prevalence of seasonal
influenza and the most widely used influenza vaccine is the inactivated influenza vaccine …

New insights for the development of efficient DNA vaccines

S Berger, Y Zeyn, E Wagner, M Bros - Microbial Biotechnology, 2024 - Wiley Online Library
Despite the great potential of DNA vaccines for a broad range of applications, ranging from
prevention of infections, over treatment of autoimmune and allergic diseases to cancer …

Flublok Quadrivalent Vaccine Adjuvanted with R-DOTAP Elicits a Robust and Multifunctional CD4 T Cell Response That Is of Greater Magnitude and Functional …

CL White, MA Glover, SK Gandhapudi, KA Richards… - Vaccines, 2024 - mdpi.com
It is clear that new approaches are needed to promote broadly protective immunity to viral
pathogens, particularly those that are prone to mutation and escape from antibody-mediated …

[HTML][HTML] Influenza B Virus Vaccine Innovation through Computational Design

MJ Pekarek, EA Weaver - Pathogens, 2024 - mdpi.com
As respiratory pathogens, influenza B viruses (IBVs) cause a significant socioeconomic
burden each year. Vaccine and antiviral development for influenza viruses has historically …

[HTML][HTML] Computationally Optimized Hemagglutinin Proteins Adjuvanted with Infectimune® Generate Broadly Protective Antibody Responses in Mice and Ferrets

JD Allen, X Zhang, JM Medina, MH Thomas… - Vaccines, 2024 - pmc.ncbi.nlm.nih.gov
Background/Objectives: Standard-of-care influenza vaccines contain antigens that are
typically derived from components of wild type (WT) influenza viruses. Often, these antigens …

A Single Dose of Inactivated Influenza Virus Vaccine Expressing COBRA Hemagglutinin Elicits Broadly-Reactive and Long-Lasting Protection

H Shi, X Zhang, TM Ross - bioRxiv, 2024 - biorxiv.org
Influenza virus infections present a pervasive global health concern resulting in millions of
hospitalizations and thousands of fatalities annually. To address the influenza antigenic …

Stimulation of an immune response by cationic lipids

W Chen, W Yan, K Johnson, G Conn… - US Patent …, 2024 - Google Patents
2022-08-05 Assigned to UNIVERSITY OF NORTH CAROLINA, CHAPEL HILL reassignment
UNIVERSITY OF NORTH CAROLINA, CHAPEL HILL ASSIGNMENT OF ASSIGNORS …

Methods of modulating immune responses with cationic lipid vaccine compositions

K Johnson, E Jacobson, F Bedu-Addo… - US Patent …, 2025 - Google Patents
The present disclosure provides vaccine compositions comprising at least one adjuvant and
at least one therapeutic factor. The disclosure also provides methods of reducing an immune …