Big data in health care is a fast-growing field and a new paradigm that is transforming case-
based studies to large-scale, data-driven research. As big data is dependent on the …

Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective
therapies are urgently needed. Several lines of evidence, from SCLC primary human …

Although small cell lung cancer (SCLC) is treated as a homogeneous disease, biopsies and
preclinical models reveal heterogeneity in transcriptomes and morphology. SCLC subtypes …

Background Small cell lung cancer (SCLC) is a deadly, high grade neuroendocrine (NE)
tumor without recognized morphologic heterogeneity. However, over 30 years ago we …

Small cell lung cancer (SCLC) tumors comprise heterogeneous mixtures of cell states,
categorized into neuroendocrine (NE) and non-neuroendocrine (non-NE) transcriptional …

Individual cells within an otherwise genetically homogenous population constantly undergo
fluctuations in their molecular state, giving rise to non-genetic heterogeneity. Such diversity …

Adopting a systems approach, we devise a general workflow to define actionable subtypes
in human cancers. Applied to small cell lung cancer (SCLC), the workflow identifies four …

Epithelial-mesenchymal heterogeneity implies that cells within the same tumor can exhibit
different phenotypes—epithelial, mesenchymal, or one or more hybrid epithelial …

It is well known that genetic mutations can drive drug resistance and lead to tumor relapse.
Here, we focus on alternate mechanisms—those without mutations, such as phenotypic …

A major question in systems biology is how to identify the core gene regulatory circuit that
governs the decision-making of a biological process. Here, we develop a computational …