Phagocytosis checkpoints as new targets for cancer immunotherapy
Cancer immunotherapies targeting adaptive immune checkpoints have substantially
improved patient outcomes across multiple metastatic and treatment-refractory cancer types …
improved patient outcomes across multiple metastatic and treatment-refractory cancer types …
FTO in cancer: functions, molecular mechanisms, and therapeutic implications
N 6-methyladenosine (m 6 A) is the most abundant internal modification in mRNA that
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer
Immune-checkpoint blockade (ICB) combined with neoadjuvant chemotherapy improves
pathological complete response in breast cancer. To understand why only a subset of …
pathological complete response in breast cancer. To understand why only a subset of …
[HTML][HTML] Targeting FTO suppresses cancer stem cell maintenance and immune evasion
Fat mass and obesity-associated protein (FTO), an RNA N 6-methyladenosine (m 6 A)
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …
Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2
Y Gu, J Cao, X Zhang, H Gao, Y Wang, J Wang, J He… - Cell research, 2022 - nature.com
Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.
However, little is known about SARS-CoV-2 host receptors with the exception of ACE2 …
However, little is known about SARS-CoV-2 host receptors with the exception of ACE2 …
Single-cell RNA-seq reveals AML hierarchies relevant to disease progression and immunity
Acute myeloid leukemia (AML) is a heterogeneous disease that resides within a complex
microenvironment, complicating efforts to understand how different cell types contribute to …
microenvironment, complicating efforts to understand how different cell types contribute to …
Immune escape and immunotherapy of acute myeloid leukemia
L Vago, I Gojo - The Journal of clinical investigation, 2020 - Am Soc Clin Investig
In spite of the recent approval of new promising targeted therapies, the clinical outcome of
patients with acute myeloid leukemia (AML) remains suboptimal, prompting the search for …
patients with acute myeloid leukemia (AML) remains suboptimal, prompting the search for …
Functions of immune checkpoint molecules beyond immune evasion
Y Zhang, J Zheng - Regulation of cancer immune checkpoints: molecular …, 2020 - Springer
Immune checkpoint molecules, including inhibitory and stimulatory immune checkpoint
molecules, are defined as ligand–receptor pairs that exert inhibitory or stimulatory effects on …
molecules, are defined as ligand–receptor pairs that exert inhibitory or stimulatory effects on …
Apolipoprotein E promotes immune suppression in pancreatic cancer through NF-κB–mediated production of CXCL1
SB Kemp, ES Carpenter, NG Steele, KL Donahue… - Cancer research, 2021 - AACR
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with few effective
therapeutic options. PDAC is characterized by an extensive fibroinflammatory stroma that …
therapeutic options. PDAC is characterized by an extensive fibroinflammatory stroma that …
Single-cell analysis reveals altered tumor microenvironments of relapse-and remission-associated pediatric acute myeloid leukemia
Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences
among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to …
among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to …