Methane monooxygenases (MMOs) mediate the facile conversion of methane into methanol
in methanotrophic bacteria with high efficiency under ambient conditions. Because the …

The cytochromes P450 constitute a large family of cysteinato-heme enzymes, 1-9 are
present in all forms of life (plants, bacteria, and mammals), and play a key role in the …

Alkanes constitute the cheapest and most abundant feedstock for organic chemicals.
However, the redistribution of CsC and CsH bonds in hydrocarbons into more sophisticated …

The introduction of oxygen into biochemical processes has brought about an evolutionary
leap in the history of life, whereby many organisms have evolved to use oxygen as part of …

Four seemingly simple transformations related to the chemistry of methane will be
addressed from mechanistic and conceptual points of view: 1) metal‐mediated …

It is proposed that spin-crossing effects can dramatically affect reaction mechanisms, rate
constants, branching ratios, and temperature behaviors of organometallic transformations …

Cytochrome P450 is one of the most versatile enzymes in nature. 1 It uses dioxygen and two
reducing equivalents to catalyze a great variety of stereospecific and regioselective oxygen …

Selective oxidation of saturated C–H bonds remains a challenge in modern chemistry. The
inert nature of such bonds requires the use of highly reactive reagents, and this poses major …

The Account discusses the phenomenon of two-state reactivity (TSR) or multistate reactivity
(MSR) in high-valent metal–oxo reagents, projecting its wide-ranging applicability starting …

The utilization of metalloporphyrins as bioinspired oxidation catalysts is an evolving topic of
research. By understanding the cytochrome P-450 mechanism of action, chemists have …