T cell lineages are defined by specialized functions and differential expression of surface
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …

The potential of cancer immunotherapy relies on the mobilization of immune cells capable of
producing antitumour cytokines and effectively killing tumour cells. These are major …

Summary Gut interleukin-17A (IL-17)-producing γδ T cells are tissue-resident cells that are
involved in both host defense and regulation of intestinal inflammation. However, factors that …

T cells of the γδ lineage are unconventional T cells with functions not restricted to MHC-
mediated antigen presentation. Because of their broad antigen specificity and NK-like …

The cytokine interleukin-23 (IL-23) is critical for development and maintenance of
autoimmune inflammation in nonlymphoid tissues; however, the mechanism through which …

Abstract γδ T cells are a unique and conserved population of lymphocytes that have been
the subject of a recent explosion of interest owing to their essential contributions to many …

Shortly after the discovery of interleukin 17 (IL-17)-producing CD4+ helper T cells (TH17
cells), it was found that γδ T cells can also secrete large amounts of this pro-inflammatory …

The unique features of gamma-delta (γδ) T cells, related to their antigen recognition
capacity, their tissue tropism, and their cytotoxic function, make these cells ideal candidates …

T cell–based cancer immunotherapy has typically relied on membrane-bound cytotoxicity
enhancers such as chimeric antigen receptors expressed in autologous αβ T cells. These …

As interest in γδ T cells grows rapidly, what key points are emerging, and where is caution
warranted? γδ T cells fulfill critical functions, as reflected in associations with vaccine …