Glioblastoma multiforme (GBM) represents the most malignant primary brain tumor in adults
with generally dismal prognosis, early clinical deterioration and high mortality. GBM is …

Glioma is the most common lethal tumor of the human brain. The median survival of patients
with primary World Health Organization grade IV glioma is only 14.6 months. The World …

Binding of programmed death ligand-1 (PD-L1) to programmed cell death protein-1 (PD1)
leads to cancer immune evasion via inhibition of T cell function. One of the defining …

Single-cell multi-omics can provide a unique perspective on tumor cellular heterogeneity.
Most previous single-cell whole-genome RNA sequencing (scWGS-RNA-seq) methods …

Patients with glioma whose tumors carry a mutation in isocitrate dehydrogenase 1
(IDH1R132H) are younger at diagnosis and live longer. IDH1 mutations co-occur with other …

Glioblastoma stem cells (GSCs) reprogram glucose metabolism by hijacking high-affinity
glucose uptake to survive in a nutritionally dynamic microenvironment. Here, we trace …

Glioma diagnosis is based on histomorphology and grading; however, such classification
does not have predictive clinical outcome after glioblastomas have developed. To date, no …

Collective behavior spans several orders of magnitude of biological organization, from cell
colonies to flocks of birds. We used time-resolved tracking of individual glioblastoma cells to …

Cohesin is a highly-conserved protein complex that plays important roles in sister chromatid
cohesion, chromatin structure, gene expression, and DNA repair. In humans, cohesin is a …

Prognostic factors and standards of care for astrocytoma, isocitrate dehydrogenase (IDH)-
mutant, CNS WHO grade 4, remain poorly defined. Here we sought to explore disease …