Design and validation of diffusion MRI models of white matter

IO Jelescu, MD Budde - Frontiers in physics, 2017 - frontiersin.org
Diffusion MRI is arguably the method of choice for characterizing white matter microstructure
in vivo. Over the typical duration of diffusion encoding, the displacement of water molecules …

[HTML][HTML] Challenges for biophysical modeling of microstructure

IO Jelescu, M Palombo, F Bagnato… - Journal of Neuroscience …, 2020 - Elsevier
The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25
years. In this review, we dwell on the various challenges along the journey of bringing a …

Diffusion MRI tractography for neurosurgery: the basics, current state, technical reliability and challenges

JYM Yang, CH Yeh, C Poupon… - Physics in Medicine & …, 2021 - iopscience.iop.org
Diffusion magnetic resonance imaging (dMRI) tractography is currently the only imaging
technique that allows for non-invasive delineation and visualisation of white matter (WM) …

Physical and numerical phantoms for the validation of brain microstructural MRI: A cookbook

E Fieremans, HH Lee - Neuroimage, 2018 - Elsevier
Phantoms, both numerical (software) and physical (hardware), can serve as a gold standard
for the validation of MRI methods probing the brain microstructure. This review aims to …

New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo

M Palombo, C Ligneul, C Najac, J Le Douce… - Proceedings of the …, 2016 - pnas.org
The brain is one of the most complex organs, and tools are lacking to assess its cellular
morphology in vivo. Here we combine original diffusion-weighted magnetic resonance (MR) …

Robust monte-carlo simulations in diffusion-mri: Effect of the substrate complexity and parameter choice on the reproducibility of results

J Rafael-Patino, D Romascano… - Frontiers in …, 2020 - frontiersin.org
Monte-Carlo Diffusion Simulations (MCDS) have been used extensively as a ground truth
tool for the validation of microstructure models for Diffusion-Weighted MRI. However …

A generative model of realistic brain cells with application to numerical simulation of the diffusion-weighted MR signal

M Palombo, DC Alexander, H Zhang - NeuroImage, 2019 - Elsevier
To date, numerical simulations of the brain tissue have been limited by their lack of realism
and flexibility. The purpose of this work is to propose a controlled and flexible generative …

Realistic Microstructure Simulator (RMS): Monte Carlo simulations of diffusion in three-dimensional cell segmentations of microscopy images

HH Lee, E Fieremans, DS Novikov - Journal of neuroscience methods, 2021 - Elsevier
Abstract Background Monte Carlo simulations of diffusion are commonly used as a model
validation tool as they are especially suitable for generating the diffusion MRI signal in …

[HTML][HTML] MEDUSA: A GPU-based tool to create realistic phantoms of the brain microstructure using tiny spheres

K Ginsburger, F Matuschke, F Poupon, JF Mangin… - Neuroimage, 2019 - Elsevier
A GPU-based tool to generate realistic phantoms of the brain microstructure is presented.
Using a spherical meshing technique which decomposes each microstructural item into a …

The effect of graphite intercalated compound particle size and exfoliation temperature on porosity and macromolecular diffusion in expanded graphite

R Goudarzi, GH Motlagh - Heliyon, 2019 - cell.com
The pore structure of expanded graphite (EG) including pore volume, pore size distribution
and surface area is investigated by mercury porosimetry, nitrogen adsorption and SEM …