Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

Over the past 2 decades, mesenchymal stem cells (MSCs) have attracted a lot of interest as
a unique therapeutic approach for a variety of diseases. MSCs are capable of self-renewal …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Human brain organoid models have emerged as a promising tool for studying human brain
development and function. These models preserve human genetics and recapitulate some …

Organoids are systems derived from pluripotent stem cells at the interface between
traditional monolayer cultures and in vivo animal models. The structural and functional …

Understanding of human brain development, dysfunction and neurological diseases has
remained limited and challenging due to inability to recapitulate human brain-specific …

Brain organoids are self‐organized, three‐dimensional (3D) aggregates derived from
pluripotent stem cells that have cell types and cellular architectures resembling those of the …

Advances in tridimensional (3D) culture approaches have led to the generation of organoids
that recapitulate cellular and physiological features of domains of the human nervous …

Innumerable studies associated with cellular differentiation, tissue response and disease
modeling have been conducted in two-dimensional (2D) culture systems or animal models …

Human cerebral organoids are unique in their development of progenitor-rich zones akin to
ventricular zones from which neuronal progenitors differentiate and migrate radially …