The appropriate coordination between epigenetic regulators is essential for spatial and
temporal regulation of gene expression and maintenance of cell identity. Cancer is a …

The histone lysine methyltransferase DOT1L (DOT1-like histone lysine methyltransferase) is
responsible for the epigenetic regulation of gene expression through specific methylation of …

Protein post-translational modifications (PTMs), which are usually enzymatically catalyzed,
are major regulators of protein activity and involved in almost all celluar processes …

Cortical neurogenesis depends on the balance between self‐renewal and differentiation of
apical progenitors (APs). Here, we study the epigenetic control of AP's division mode by …

Vesicle trafficking is a fundamental process that allows for the sorting and transport of
specific proteins (ie," cargoes") to different compartments of eukaryotic cells. Cargo …

The reversible and precise temporal and spatial regulation of histone lysine
methyltransferases (KMTs) is essential for epigenome homeostasis. The dysregulation of …

Histone modifications are key factors in chromatin packaging, and are responsible for gene
regulation during cell fate determination and development. Abnormal alterations in histone …

Histone lysine methylation is a post-translational modification that plays a key role in the
epigenetic regulation of a broad spectrum of biological processes. Moreover, the …

While a protein primary structure is determined by genetic code, its specific functional form is
mostly achieved in a dynamic interplay that includes actions of many enzymes involved in …

Histone modification regulates replication-coupled nucleosome assembly, DNA damage
repair, and gene transcription. Changes or mutations in factors involved in nucleosome …