Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …

While protein therapeutics are one of the most successful class of drug molecules, they are
expensive and not suited for treating chronic disorders that require long-term dosing. Adeno …

Drug delivery to the brain is crucial in the treatment for central nervous system disorders.
While significant progress has been made in recent years, there are still major challenges in …

Propriospinal interneurons (INs) communicate information over short and long distances
within the spinal cord. They act to coordinate different parts of the body by linking motor …

Spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) are severe nervous
system diseases characterized by the degeneration of lower motor neurons. They share a …

Virus-mediated gene therapy has the potential to deliver exogenous genetic material into
specific cell types to promote survival and counteract disease. This is particularly enticing for …

The motor system controls muscle movement through lower motor neurons in the spinal cord
and brainstem. Lower motor neurons are efferent neurons in the central nervous system …

Axonal transport is the active process whereby neurons transport cargoes such as
organelles and proteins anterogradely from the cell body to the axon terminal and …

Knowledge regarding the relationship between muscles and the corresponding motor
neurons would allow therapeutic genes to transport into specific spinal cord segments …

Axonal transport maintains neuronal homeostasis by enabling the bidirectional trafficking of
diverse organelles and cargoes. Disruptions in axonal transport have devastating …