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Organization and regulation of gene transcription
The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …
studies have elucidated mechanisms that govern the regulation of transcription by RNA …
Understanding biochemistry: structure and function of nucleic acids
S Minchin, J Lodge - Essays in biochemistry, 2019 - portlandpress.com
Nucleic acids, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), carry genetic
information which is read in cells to make the RNA and proteins by which living things …
information which is read in cells to make the RNA and proteins by which living things …
NF-κB, the first quarter-century: remarkable progress and outstanding questions
The ability to sense and adjust to the environment is crucial to life. For multicellular
organisms, the ability to respond to external changes is essential not only for survival but …
organisms, the ability to respond to external changes is essential not only for survival but …
Regulation and function of DNA methylation in plants and animals
DNA methylation is an important epigenetic mark involved in diverse biological processes.
In plants, DNA methylation can be established through the RNA-directed DNA methylation …
In plants, DNA methylation can be established through the RNA-directed DNA methylation …
Conservation between the RNA polymerase I, II, and III transcription initiation machineries
Recent studies of the three eukaryotic transcription machineries revealed that all initiation
complexes share a conserved core. This core consists of the RNA polymerase (I, II, or III), the …
complexes share a conserved core. This core consists of the RNA polymerase (I, II, or III), the …
Disruption of Mediator rescues the stunted growth of a lignin-deficient Arabidopsis mutant
Lignin is a phenylpropanoid-derived heteropolymer important for the strength and rigidity of
the plant secondary cell wall,. Genetic disruption of lignin biosynthesis has been proposed …
the plant secondary cell wall,. Genetic disruption of lignin biosynthesis has been proposed …
Histone marks in the 'driver's seat': functional roles in steering the transcription cycle
Particular chromatin modifications are associated with different states of gene transcription,
yet our understanding of which modifications are causal 'drivers' in promoting transcription is …
yet our understanding of which modifications are causal 'drivers' in promoting transcription is …
[HTML][HTML] Gene expression is circular: factors for mRNA degradation also foster mRNA synthesis
Maintaining proper mRNA levels is a key aspect in the regulation of gene expression. The
balance between mRNA synthesis and decay determines these levels. We demonstrate that …
balance between mRNA synthesis and decay determines these levels. We demonstrate that …
[HTML][HTML] AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia
Chromosomal translocations involving the MLL gene are associated with infant acute
lymphoblastic and mixed lineage leukemia. There are a large number of translocation …
lymphoblastic and mixed lineage leukemia. There are a large number of translocation …
Structural visualization of key steps in human transcription initiation
Eukaryotic transcription initiation requires the assembly of general transcription factors into a
pre-initiation complex that ensures the accurate loading of RNA polymerase II (Pol II) at the …
pre-initiation complex that ensures the accurate loading of RNA polymerase II (Pol II) at the …