T-type calcium channels perform crucial physiological roles across a wide spectrum of
tissues, spanning both neuronal and non-neuronal system. For instance, they serve as …

Autism spectrum disorder (ASD) is a complex disorder of neurodevelopment, the function of
long noncoding RNA (lncRNA) in ASD remains essentially unknown. In the present study …

Opioid craving and relapse vulnerability is associated with severe and persistent sleep and
circadian rhythm disruptions. Understanding the neurobiological underpinnings of circadian …

The expanded use of hypothesis-free gene analysis methods in autism research has
significantly increased the number of genetic risk factors associated with the pathogenesis of …

Abstract Apolipoprotein E4 (ApoE4) is the most important and prevalent risk factor for late-
onset Alzheimer's disease (AD). The isoelectric point of ApoE4 matches the pH of the early …

Cancer-related cognitive impairment (CRCI) is a consequence of chemotherapy and
extracranial radiation therapy (ECRT). Our prior work demonstrated gliosis in the brain …

Abstract Na+ (K+)/H+ exchanger 6 (NHE6) on synaptic vesicle (SV) is critical for the
presynaptic regulation of quantal size at the glutamatergic synapses by converting the …

Missense mutations in the human secretary carrier-associated membrane protein 5
(SCAMP5) cause a variety of neurological disorders including neurodevelopmental delay …

Opioid craving and the vulnerability to relapse is associated with severe and persistent
disruptions to sleep and circadian rhythms. Investigations into the cellular and molecular …

Mutations in the endosomal Na+/H+ exchanger 6 (NHE6) cause Christianson syndrome, an
X-linked neurological disorder. NHE6 functions in regulation of endosome acidification and …