EANO guideline on the diagnosis and management of meningiomas
Meningiomas are the most common intracranial tumors. Yet, only few controlled clinical trials
have been conducted to guide clinical decision making, resulting in variations of …
have been conducted to guide clinical decision making, resulting in variations of …
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
R Cunningham, CG Hansen - Clinical Science, 2022 - portlandpress.com
Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …
signalling pathways. One such pathway that has garnered much attention in the field of …
Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities
Meningiomas are the most common primary intracranial tumors. There are no effective
medical therapies for meningioma patients, and new treatments have been encumbered by …
medical therapies for meningioma patients, and new treatments have been encumbered by …
[HTML][HTML] YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance
YAP1 is a transcriptional co-activator whose activity is controlled by the Hippo signaling
pathway. In addition to important functions in normal tissue homeostasis and regeneration …
pathway. In addition to important functions in normal tissue homeostasis and regeneration …
Molecular alterations in meningioma: prognostic and therapeutic perspectives
The mutational landscape of meningioma has expanded following the use of the new
genetic sequencing approaches. Novel mutations have been characterized and reveal their …
genetic sequencing approaches. Novel mutations have been characterized and reveal their …
Meningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients
Meningiomas are the most common primary intracranial tumors in adults and are increasing
in incidence due to the aging population and increased access to neuroimaging. While most …
in incidence due to the aging population and increased access to neuroimaging. While most …
Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis
YAP1 is a transcriptional coactivator and the principal effector of the Hippo signaling
pathway, which is causally implicated in human cancer. Several YAP1 gene fusions have …
pathway, which is causally implicated in human cancer. Several YAP1 gene fusions have …
Intracranial mesenchymal tumor with FET‐CREB fusion—a unifying diagnosis for the spectrum of intracranial myxoid mesenchymal tumors and angiomatoid fibrous …
EA Sloan, J Chiang, JE Villanueva‐Meyer… - Brain …, 2021 - Wiley Online Library
Intracranial mesenchymal tumors with FET‐CREB fusions are a recently described group of
neoplasms in children and young adults characterized by fusion of a FET family gene …
neoplasms in children and young adults characterized by fusion of a FET family gene …
The oncogenic fusion landscape in pediatric CNS neoplasms
Pediatric neoplasms in the central nervous system (CNS) are the leading cause of cancer-
related deaths in children. Recent developments in molecular analyses have greatly …
related deaths in children. Recent developments in molecular analyses have greatly …
Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2 mutant meningiomas in mice
YAP1 is a transcriptional coactivator regulated by the Hippo signaling pathway, including
NF2. Meningiomas are the most common primary brain tumors; a large percentage exhibit …
NF2. Meningiomas are the most common primary brain tumors; a large percentage exhibit …