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Emerging time-resolved x-ray diffraction approaches for protein dynamics
DR Hekstra - Annual review of biophysics, 2023 - annualreviews.org
Proteins guide the flows of information, energy, and matter that make life possible by
accelerating transport and chemical reactions, by allosterically modulating these reactions …
accelerating transport and chemical reactions, by allosterically modulating these reactions …
Best practices for time-resolved serial synchrotron crystallography
EC Schulz, BA Yorke, AR Pearson… - Biological …, 2022 - journals.iucr.org
With recent developments in X-ray sources, instrumentation and data-analysis tools, time-
resolved crystallographic experiments, which were originally the preserve of a few expert …
resolved crystallographic experiments, which were originally the preserve of a few expert …
Defining a new nomenclature for the structures of active and inactive kinases
V Modi, RL Dunbrack Jr - Proceedings of the National Academy of …, 2019 - pnas.org
Targeting protein kinases is an important strategy for intervention in cancer. Inhibitors are
directed at the active conformation or a variety of inactive conformations. While attempts …
directed at the active conformation or a variety of inactive conformations. While attempts …
Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase
The enzyme soybean lipoxygenase (SLO) provides a prototype for deep tunneling
mechanisms in hydrogen transfer catalysis. This work combines room temperature X-ray …
mechanisms in hydrogen transfer catalysis. This work combines room temperature X-ray …
Ligand binding remodels protein side-chain conformational heterogeneity
SA Wankowicz, SH de Oliveira, DW Hogan… - Elife, 2022 - elifesciences.org
While protein conformational heterogeneity plays an important role in many aspects of
biological function, including ligand binding, its impact has been difficult to quantify …
biological function, including ligand binding, its impact has been difficult to quantify …
Determining the interconverting conformations of dynamic proteins in atomic detail is a
major challenge for structural biology. Conformational heterogeneity in the active site of the …
major challenge for structural biology. Conformational heterogeneity in the active site of the …
Macromolecular room temperature crystallography
M Fischer - Quarterly Reviews of Biophysics, 2021 - cambridge.org
X-ray crystallography enables detailed structural studies of proteins to understand and
modulate their function. Conducting crystallographic experiments at cryogenic temperatures …
modulate their function. Conducting crystallographic experiments at cryogenic temperatures …
Rescue of conformational dynamics in enzyme catalysis by directed evolution
Rational design and directed evolution have proved to be successful approaches to
increase catalytic efficiencies of both natural and artificial enzymes. Protein dynamics is …
increase catalytic efficiencies of both natural and artificial enzymes. Protein dynamics is …
Functional roles of enzyme dynamics in accelerating active site chemistry: Emerging techniques and changing concepts
S Gao, JP Klinman - Current opinion in structural biology, 2022 - Elsevier
With the growing acceptance of the contribution of protein conformational ensembles to
enzyme catalysis and regulation, research in the field of protein dynamics has shifted toward …
enzyme catalysis and regulation, research in the field of protein dynamics has shifted toward …