Phosphoglycerate mutase 5 exacerbates alcoholic cardiomyopathy in male mice by inducing prohibitin‐2 dephosphorylation and impairing mitochondrial quality …

J Tao, J Qiu, J Zheng, R Li, X Chang… - Clinical and …, 2024 - Wiley Online Library
Background The induction of mitochondrial quality control (MQC) mechanisms is essential
for the re‐establishment of mitochondrial homeostasis and cellular bioenergetics during …

Glutathione S-transferase: A keystone in Parkinson's disease pathogenesis and therapy

P Padhan, N Kumar, S Verma - Molecular and Cellular Neuroscience, 2024 - Elsevier
Parkinson's disease is a progressive neurodegenerative disorder that predominantly affects
motor function due to the loss of dopaminergic neurons in the substantia nigra. It presents …

Calcium bridges built by mitochondria-associated endoplasmic reticulum membranes: potential targets for neural repair in neurological diseases

Y Peng, L Zhou, Y **, D Wu, N Chen… - Neural Regeneration …, 2025 - journals.lww.com
The exchange of information and materials between organelles plays a crucial role in
regulating cellular physiological functions and metabolic levels. Mitochondria-associated …

Protective effects of Parkin knockout on asthma-induced changes in juvenile mice: inflammation, airway resistance, and oxidative stress

HF Zhan, WJ Lin - Journal of Asthma, 2025 - Taylor & Francis
Objective This study aimed to explore the effects of Parkin (Prkn) knockout in a juvenile
mouse model of asthma. Methods Prkn knockout (KO) and wild type (WT) mice were utilized …

Mitochondria‐Related Genome‐Wide Mendelian Randomization Identifies Putatively Causal Genes for Neurodegenerative Diseases

Z Wang, Y Sun, Z Bai, M Li, D Kong… - Movement Disorders, 2025 - Wiley Online Library
Background Mitochondrial dysfunction is increasingly recognized as a key factor in
neurodegenerative diseases (NDDs), underscoring the therapeutic potential of targeting …

[HTML][HTML] Methamphetamine Increases Tubulo-Vesicular Areas While Dissipating Proteins from Vesicles Involved in Cell Clearance

G Lazzeri, P Lenzi, CL Busceti… - International Journal of …, 2024 - mdpi.com
Cytopathology induced by methamphetamine (METH) is reminiscent of degenerative
disorders such as Parkinson's disease, and it is characterized by membrane organelles …

Computational Studies on the Functional and Structural Impact of Pathogenic Mutations in Enzymes

UC Dissanayake, A Roy, Y Maghsoud, S Polara… - 2024 - chemrxiv.org
Enzymes are critical biological catalysts involved in maintaining the intricate balance of
metabolic processes within living organisms. Mutations in enzymes can result in disruptions …

[HTML][HTML] Molecular Mechanisms Behind Neurodegenerative Diseases: Alzheimer's and Parkinson's

Y Barony - stem-journal.com
Neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease
(PD), are major health challenges, particularly in aging populations. These conditions …