Clinical implementation of pharmacogenomics for personalized precision medicine: barriers and solutions
Clinical implementation of pharmacogenomics (PGx) leads to personalized medicine, which
improves the efficacy, safety, and cost-effectiveness of treatments. Although PGx-based …
improves the efficacy, safety, and cost-effectiveness of treatments. Although PGx-based …
A Comprehensive Review of HLA and Severe Cutaneous Adverse Drug Reactions: Implication for Clinical Pharmacogenomics and Precision Medicine
Human leukocyte antigen (HLA) encoded by the HLA gene is an important modulator for
immune responses and drug hypersensitivity reactions as well. Genetic polymorphisms of …
immune responses and drug hypersensitivity reactions as well. Genetic polymorphisms of …
Pharmacogenomic testing: clinical evidence and implementation challenges
C Hippman, C Nislow - Journal of personalized medicine, 2019 - mdpi.com
Pharmacogenomics can enhance patient care by enabling treatments tailored to genetic
make-up and lowering risk of serious adverse events. As of June 2019, there are 132 …
make-up and lowering risk of serious adverse events. As of June 2019, there are 132 …
Advancing pharmacogenomics from single-gene to preemptive testing
Pharmacogenomic testing can be an effective tool to enhance medication safety and
efficacy. Pharmacogenomically actionable medications are widely used, and approximately …
efficacy. Pharmacogenomically actionable medications are widely used, and approximately …
Pharmacogenomic clinical decision support: a review, how‐to guide, and future vision
Clinical decision support (CDS) is an essential part of any pharmacogenomics (PGx)
implementation. Increasingly, institutions have implemented CDS tools in the clinical setting …
implementation. Increasingly, institutions have implemented CDS tools in the clinical setting …
CYP2D6 pharmacogenetics and phenoconversion in personalized medicine
Introduction CYP2D6 contributes to the metabolism of approximately 20–25% of drugs.
However, CYP2D6 is highly polymorphic and different alleles can lead to impacts ranging …
However, CYP2D6 is highly polymorphic and different alleles can lead to impacts ranging …
[HTML][HTML] Challenges and lessons learned from clinical pharmacogenetic implementation of multiple gene–drug pairs across ambulatory care settings
EJ Cicali, KW Weitzel, AR Elsey, FA Orlando… - Genetics in …, 2019 - Elsevier
Purpose Incorporating a patient's genotype into the clinical decision-making process is one
approach to precision medicine. The University of Florida (UF) Health Precision Medicine …
approach to precision medicine. The University of Florida (UF) Health Precision Medicine …
[HTML][HTML] Pharmacogenetic testing knowledge and attitudes among pediatric psychiatrists and pediatricians in Alberta, Canada
CD Jessel, A Al Maruf, A Oomen… - Journal of the …, 2022 - ncbi.nlm.nih.gov
Objective To assess knowledge, attitudes, and barriers as well as ethical, legal and social
concerns towards pharmacogenetic (PGx) testing among pediatric psychiatrists and …
concerns towards pharmacogenetic (PGx) testing among pediatric psychiatrists and …
Precision psychiatry in clinical practice
The treatment of depression represents a major challenge for healthcare systems and
choosing among the many available drugs without objective guidance criteria is an error …
choosing among the many available drugs without objective guidance criteria is an error …
Electronic medical record‐integrated pharmacogenomics and related clinical decision support concepts
PJ Caraballo, SJ Bielinski, JL St. Sauver… - Clinical …, 2017 - Wiley Online Library
Advances in pharmacogenomics (PGx) have the potential to transform healthcare by
allowing precision medicine to become a reality. However, PGx knowledge is new, complex …
allowing precision medicine to become a reality. However, PGx knowledge is new, complex …