RNA has emerged as a revolutionary and important tool in the battle against emerging
infectious diseases, with roles extending beyond its applications in vaccines, in which it is …

The discovery of therapeutic miRNAs is one of the most exciting challenges for
pharmaceutical companies. Since the first miRNA was discovered in 1993, our knowledge of …

Experimental introduction of RNA into cells can be used in certain biological systems to
interfere with the function of an endogenous gene,. Such effects have been proposed to …

Highlights•Unlike RNA decay, RNAi results in continued rounds of post-transcriptional
silencing.•Pathways exist for both uncleaved and small RNA-sliced transcripts to enter …

MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the
message or inhibit translation. The specific function of most mammalian miRNAs is …

Gene silencing through RNA interference (RNAi) is carried out by RISC, the RNA-induced
silencing complex. RISC contains two signature components, small interfering RNAs …

Chemotherapeutic agents have certain limitations when it comes to treating cancer, the most
important being severe side effects along with multidrug resistance developed against them …

Genome-wide genetic approaches have proven useful for examining pathways of biological
significance in model organisms such as Saccharomyces cerevisiae, Drosophila …

MicroRNAs (miRNAs) are an extensive class of∼ 22-nucleotide noncoding RNAs thought to
regulate gene expression in metazoans. We find that miRNAs are also present in plants …

We predict regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs
with near complementarity. Complementary sites within predicted targets are conserved in …