Physical access to DNA is a highly dynamic property of chromatin that plays an essential
role in establishing and maintaining cellular identity. The organization of accessible …

As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …

DNA methylation is frequently described as a'silencing'epigenetic mark, and indeed this
function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved …

Single-cell epigenome sequencing techniques have recently been developed. However, the
combination of different layers of epigenome sequencing in an individual cell has not yet …

Histone modifications and chromatin-associated protein complexes are crucially involved in
the control of gene expression, supervising cell fate decisions and differentiation. Many …

The ectopic expression of transcription factors can reprogram cell fate, yet it is unknown how
the initial binding of factors to the genome relates functionally to the binding seen in the …

Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …

A three-dimensional chromatin state underpins the structural and functional basis of the
genome by bringing regulatory elements and genes into close spatial proximity to ensure …

Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in
physiological aspects of cell-type determination and tissue homeostasis, their potential …

The ability to maintain quiescence is critical for the long-term maintenance of a functional
stem cell pool. To date, the epigenetic and transcriptional characteristics of quiescent stem …