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Opportunities and challenges in cardiac tissue engineering from an analysis of two decades of advances
Engineered human cardiac tissues facilitate progress in regenerative medicine, disease
modelling and drug development. In this Perspective, we reflect on the most notable …
modelling and drug development. In this Perspective, we reflect on the most notable …
Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells
Tissue-like structures from human pluripotent stem cells containing multiple cell types are
transforming our ability to model and understand human development and disease. Here we …
transforming our ability to model and understand human development and disease. Here we …
[HTML][HTML] Vascular cells improve functionality of human cardiac organoids
Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular
cells within human cardiac organoids (hCOs) enhance their maturation, force of contraction …
cells within human cardiac organoids (hCOs) enhance their maturation, force of contraction …
In situ expansion, differentiation, and electromechanical coupling of human cardiac muscle in a 3D bioprinted, chambered organoid
Rationale: One goal of cardiac tissue engineering is the generation of a living, human pump
in vitro that could replace animal models and eventually serve as an in vivo therapeutic …
in vitro that could replace animal models and eventually serve as an in vivo therapeutic …
Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells
Cardiomyocytes and endothelial cells in the heart are in close proximity and in constant
dialogue. Endothelium regulates the size of the heart, supplies oxygen to the myocardium …
dialogue. Endothelium regulates the size of the heart, supplies oxygen to the myocardium …
Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function
Human iPS cell (iPSC)-derived cardiomyocytes (CMs) hold promise for drug discovery for
heart diseases and cardiac toxicity tests. To utilize human iPSC-derived CMs, the …
heart diseases and cardiac toxicity tests. To utilize human iPSC-derived CMs, the …
Naturally engineered maturation of cardiomyocytes
Ischemic heart disease remains one of the most prominent causes of mortalities worldwide
with heart transplantation being the gold-standard treatment option. However, due to the …
with heart transplantation being the gold-standard treatment option. However, due to the …
The triad of nanotechnology, cell signalling, and scaffold implantation for the successful repair of damaged organs: An overview on soft-tissue engineering
As a milestone in therapeutic fields, tissue engineering has offered an alternative strategy to
address unmet clinical needs for the repair and replacement of human damaged organs …
address unmet clinical needs for the repair and replacement of human damaged organs …
[HTML][HTML] Modeling cardiovascular diseases with hiPSC-derived cardiomyocytes in 2D and 3D cultures
In the last decade, the generation of cardiac disease models based on human-induced
pluripotent stem cells (hiPSCs) has become of common use, providing new opportunities to …
pluripotent stem cells (hiPSCs) has become of common use, providing new opportunities to …
The next generation of endothelial differentiation: tissue-specific ECs
Endothelial cells (ECs) sense and respond to fluid flow and regulate immune cell trafficking
in all organs. Despite sharing the same mesodermal origin, ECs exhibit heterogeneous …
in all organs. Despite sharing the same mesodermal origin, ECs exhibit heterogeneous …