Four adenosine receptors have been cloned and characterized from several mammalian
species. The receptors are named adenosine A 1, A 2A, A 2B, and A 3. The A 2A and A 2B …

Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the
world. There is growing evidence that they could also be promising therapeutic targets in a …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

Calcium-activated nonselective (CAN) cation channels are expressed in various excitable
and nonexcitable cells supporting important cellular responses such as neuronal bursting …

Four adenosine receptors have been cloned from many mammalian and some non-
mammalian species. In each case the translated part of the receptor is encoded by two …

The purine nucleoside adenosine acts via four distinct adenosine receptor subtypes: the
adenosine A1, A2A, A2B, and A3 receptor. They are all G protein-coupled receptors (GPCR) …

Adenosine accumulation during ischemia and inflammation protects tissues from injury. In
ischemic tissues adenosine accumulates due to inhibition of adenosine kinase, and in …

Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of Trk
receptor tyrosine kinases. Binding of neurotrophins to Trk receptors results in receptor …

Microglial activation by purines and pyrimidines is reviewed, with emphasis on the actions of
adenosine 5!-triphosphate (ATP) on chemotaxis or releases of plasminogen and cytokines …

Adenosine promotes tissue protection and repair through four general modes of action:
increased oxygen supply/demand ratio, preconditioning, anti-inflammatory effects, and …