Src kinase (Src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and
proliferation. Many studies have shown that Src plays multiple roles in macrophage …

Cell motility is stimulated by extracellular stimuli and initiated by intracellular signaling
proteins that localize to sites of cell contact with the extracellular matrix termed focal …

The Cas family of multiadaptor and scaffold molecules has an essential role in intracellular
signaling events. Although these proteins do not have enzymatic or transcriptional activity …

The role of mechanical properties in cancer disease and inflammation is still
underinvestigated and even ignored in many oncological and immunological reviews. In …

An approach combining small-angle X-ray solution scattering (SAXS) data with coarse-
grained (CG) simulations is developed to characterize the assembly states of Hck, a member …

The molecular coupling of CAS and Crk in response to integrin activation is an evolutionary
conserved signaling module that controls cell proliferation, survival and migration. However …

Tyrosine kinase receptors and integrins play essential roles in tumor cell invasion and
metastasis. Previously, we showed that epidermal growth factor (EGF) stimulation of …

I ntegrin signaling has a critical function in organizing cells in tissues during both embryonic
development and tissue repair. Following their binding to the extracellular ligands, the …

Regulation of the actin-myosin cytoskeleton plays a central role in cell migration and cancer
progression. Here, we report the discovery of a cytoskeleton-associated kinase …

Overexpression and enhanced activation of the epidermal growth factor (EGF) receptor are
frequent events in human cancers that correlate with poor prognosis. Anti-phosphotyrosine …