The poor prognosis and rising incidence of esophageal cancer highlight the need for
improved detection and prediction methods that are essential prior to treatment. Esophageal …

Neoplasms are microcosms of evolution. Within a neoplasm, a mosaic of mutant cells
compete for space and resources, evade predation by the immune system and can even …

BACKGROUND Incidence rates for esophageal adenocarcinoma previously were reported
to be increasing rapidly, especially among white males. Rates for gastric cardia …

Polyploidy is a frequent phenomenon in the eukaryotic world, but the biological properties of
polyploid cells are not well understood. During evolution, polyploidy is thought to be an …

Barrett's esophagus is thought to progress to esophageal adenocarcinoma (EAC) through a
stepwise progression with loss of CDKN2A followed by TP53 inactivation and aneuploidy …

Although nearly all mammalian species are diploid, whole-genome duplications occur in
select mammalian tissues as part of normal development. Such programmed …

Background. Incidence rates have risen rapidly for esophageal adenocarcinoma and
moderately for gastric cardia adenocarcinoma, while rates have remained stable for …

Polyploid cells, which contain multiple copies of the typically diploid genome, are
widespread in plants and animals. Polyploidization can be developmentally programmed or …

BACKGROUND Gastroesophageal reflux disease (GERD) is a common cause of morbidity
and health-care utilization in many countries. Obesity is a potentially modifiable risk factor …

Background: Barrett's esophagus is a strong risk factor for esophageal adenocarcinoma, but
little is known about its associations with body mass index (BMI) or abdominal obesity …