Using machine learning approaches for multi-omics data analysis: A review

PS Reel, S Reel, E Pearson, E Trucco… - Biotechnology advances, 2021 - Elsevier
With the development of modern high-throughput omic measurement platforms, it has
become essential for biomedical studies to undertake an integrative (combined) approach to …

Understudied proteins: opportunities and challenges for functional proteomics

G Kustatscher, T Collins, AC Gingras, T Guo… - Nature …, 2022 - nature.com
Most research aiming at understanding the molecular foundations of life and disease has
focused on a limited set of increasingly well-known proteins while the biological functions of …

Breast cancer heterogeneity and its implication in personalized precision therapy

L Guo, D Kong, J Liu, L Zhan, L Luo, W Zheng… - … hematology & oncology, 2023 - Springer
Breast cancer heterogeneity determines cancer progression, treatment effects, and
prognosis. However, the precise mechanism for this heterogeneity remains unknown owing …

Genetics meets proteomics: perspectives for large population-based studies

K Suhre, MI McCarthy, JM Schwenk - Nature Reviews Genetics, 2021 - nature.com
Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …

Multi-pass, single-molecule nanopore reading of long protein strands

K Motone, D Kontogiorgos-Heintz, J Wee, K Kurihara… - Nature, 2024 - nature.com
The ability to sequence single protein molecules in their native, full-length form would
enable a more comprehensive understanding of proteomic diversity. Current technologies …

Biological nanopore approach for single‐molecule protein sequencing

ZL Hu, MZ Huo, YL Ying, YT Long - Angewandte Chemie, 2021 - Wiley Online Library
Proteins are responsible for the occurrence and treatment of many diseases, and therefore
protein sequencing will revolutionize proteomics and clinical diagnostics. Biological …

Paleoproteomics

C Warinner, K Korzow Richter, MJ Collins - Chemical reviews, 2022 - ACS Publications
Paleoproteomics, the study of ancient proteins, is a rapidly growing field at the intersection of
molecular biology, paleontology, archaeology, paleoecology, and history. Paleoproteomics …

Protein identification by nanopore peptide profiling

FLR Lucas, RCA Versloot, L Yakovlieva… - Nature …, 2021 - nature.com
Nanopores are single-molecule sensors used in nucleic acid analysis, whereas their
applicability towards full protein identification has yet to be demonstrated. Here, we show …

Engineering biological nanopore approaches toward protein sequencing

X Wei, T Penkauskas, JE Reiner, C Kennard… - ACS …, 2023 - ACS Publications
Biotechnological innovations have vastly improved the capacity to perform large-scale
protein studies, while the methods we have for identifying and quantifying individual proteins …

Paracrine mechanisms of mesenchymal stromal cells in angiogenesis

S Maacha, H Sidahmed, S Jacob… - Stem cells …, 2020 - Wiley Online Library
The role of the mesenchymal stromal cell‐(MSC‐) derived secretome is becoming
increasingly intriguing from a clinical perspective due to its ability to stimulate endogenous …