Adipose tissue aging is regulated by an altered immune system

YX Zhang, MY Ou, ZH Yang, Y Sun, QF Li… - Frontiers in …, 2023 - frontiersin.org
Adipose tissue is a widely distributed organ that plays a critical role in age-related
physiological dysfunctions as an important source of chronic sterile low-grade inflammation …

Orchestration of the adipose tissue immune landscape by adipocytes

D Bradley, T Deng, D Shantaram… - Annual review of …, 2024 - annualreviews.org
Obesity is epidemic and of great concern because of its comorbid and costly inflammatory-
driven complications. Extensive investigations in mice have elucidated highly coordinated …

Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis

SK Wculek, I Heras-Murillo, A Mastrangelo, D Mañanes… - Immunity, 2023 - cell.com
In vitro studies have associated oxidative phosphorylation (OXPHOS) with anti-inflammatory
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …

Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production

AD Hildreth, ET Padilla, M Gupta, YY Wong, R Sun… - Nature …, 2023 - nature.com
Obesity is associated with chronic low-grade white adipose tissue (WAT) inflammation that
can contribute to the development of insulin resistance in mammals. Previous studies have …

Anti-inflammatory mechanisms of dietary flavones: tap** into nature to control chronic inflammation in obesity and cancer

A Kariagina, AI Doseff - International journal of molecular sciences, 2022 - mdpi.com
Flavones are natural phytochemicals broadly distributed in our diet. Their anti-inflammatory
properties provide unique opportunities to control the innate immune system and …

[HTML][HTML] Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain

HY Zhou, X Feng, LW Wang, R Zhou, H Sun, X Chen… - Cell Metabolism, 2023 - cell.com
Weight regain after weight loss is a major challenge in the treatment of obesity. Immune cells
adapt to fluctuating nutritional stress, but their roles in regulating weight regain remain …

Chinese chestnut shell polyphenol extract regulates the JAK2/STAT3 pathway to alleviate high-fat diet-induced, leptin-resistant obesity in mice

S Liu, W Jiang, C Liu, S Guo, H Wang, X Chang - Food & Function, 2023 - pubs.rsc.org
Chinese chestnut shell is a by-product of chestnut food processing and is rich in
polyphenols. This study sought to investigate the effect of chestnut shell polyphenol extract …

MICa/b‐dependent activation of natural killer cells by CD64+ inflammatory type 2 dendritic cells contributes to autoimmunity

I Sánchez‐Cerrillo, D Calzada‐Fraile… - The EMBO …, 2023 - embopress.org
Primary Sjögren's syndrome (pSS) is an inflammatory autoimmune disorder largely
mediated by type I and II interferon (IFN). The potential contribution of innate immune cells …

Contribution of NKT cells and CD1d-expressing cells in obesity-associated adipose tissue inflammation

M Satoh, K Iwabuchi - Frontiers in immunology, 2024 - frontiersin.org
Natural killer T (NKT) cell are members of the innate-like T lymphocytes and recognizes lipid
antigens presented by CD1d-expressing cells. Obesity-associated inflammation in adipose …

Conventional type 1 dendritic cells protect against gut barrier disruption via maintaining Akkermansia muciniphila in alcoholic steatohepatitis

L Hao, W Zhong, J Woo, X Wei, H Ma, H Dong… - Hepatology, 2023 - journals.lww.com
Hepatology AASLD Publications Hepatology Liver Transplantation Hepatology Communications
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