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Autophagy in major human diseases
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
[HTML][HTML] Autophagy in inflammation, infection, and immunometabolism
Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …
The double-edged functions of necroptosis
Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it
has been implicated in the pathogenesis of many diseases, there is evidence to support that …
has been implicated in the pathogenesis of many diseases, there is evidence to support that …
Cell death pathways: intricate connections and disease implications
M Kist, D Vucic - The EMBO Journal, 2021 - embopress.org
Various forms of cell death have been identified over the last decades with each relying on a
different subset of proteins for the activation and execution of their respective pathway (s). In …
different subset of proteins for the activation and execution of their respective pathway (s). In …
Effects of intestinal fungi and viruses on immune responses and inflammatory bowel diseases
The intestinal microbiota comprises diverse fungal and viral components, in addition to
bacteria. These microbes interact with the immune system and affect human physiology …
bacteria. These microbes interact with the immune system and affect human physiology …
[HTML][HTML] IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment
The Th17 cell-lineage-defining cytokine IL-17A contributes to host defense and inflammatory
disease by coordinating multicellular immune responses. The IL-17 receptor (IL-17RA) is …
disease by coordinating multicellular immune responses. The IL-17 receptor (IL-17RA) is …
p53 suppresses MHC class II presentation by intestinal epithelium to protect against radiation-induced gastrointestinal syndrome
Radiation-induced gastrointestinal syndrome is a major complication and limiting factor for
radiotherapy. Tumor suppressor p53 has a protective role in radiation-induced …
radiotherapy. Tumor suppressor p53 has a protective role in radiation-induced …
[HTML][HTML] Inflammation-induced epigenetic imprinting regulates intestinal stem cells
It remains unknown whether and how intestinal stem cells (ISCs) adapt to inflammatory
exposure and whether the adaptation leaves scars that will affect their subsequent …
exposure and whether the adaptation leaves scars that will affect their subsequent …
Immunomodulation by enteric viruses
Enteric viruses display intricate adaptations to the host mucosal immune system to
successfully reproduce in the gastrointestinal tract and cause maladies ranging from …
successfully reproduce in the gastrointestinal tract and cause maladies ranging from …
The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death
Loss of Paneth cells and their antimicrobial granules compromises the intestinal epithelial
barrier and is associated with Crohn's disease, a major type of inflammatory bowel …
barrier and is associated with Crohn's disease, a major type of inflammatory bowel …