Lysosomes are catabolic organelles that govern numerous cellular processes, including
macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in …

Macro (Autophagy) is a catabolic process that relies on the cooperative function of two
organelles: the lysosome and the autophagosome. The recent discovery of a transcriptional …

Abstract The Genitourinary Pathology Society (GUPS) reviewed recent advances in renal
neoplasia, particularly post-2016 World Health Organization (WHO) classification, to provide …

The classification working group of the International Society of Urological Pathology
consensus conference on renal neoplasia was in charge of making recommendations …

This WHO classification covers tumors of soft tissue and bone including inherited tumor
syndromes. Each entity is extensively discussed with information on clinicopathological …

The pivotal role of lysosomes in cellular processes is increasingly appreciated. An
understanding of the balanced interplay between the activity of acidic hydrolases, lysosomal …

The treatment landscape of metastatic renal cell carcinoma (RCC) has been revolutionized
over the past two decades, bringing forth an era in which more than a dozen therapeutic …

Despite nearly two decades passing since the discovery of gene fusions involving TFE3 or
TFEB in sporadic renal cell carcinoma (RCC), the molecular mechanisms underlying the …

The MiT subfamily of transcription factors includes TFE3, TFEB, TFC, and MiTF. Gene
fusions involving two of these transcription factors have been identified in renal cell …

Accumulating evidence suggests that renal cell tumors represent a group of histologically
and molecularly heterogeneous diseases, even within the same histological subtype. In …