The dynamic regulation of NAD metabolism in mitochondria
LR Stein, S Imai - Trends in Endocrinology & Metabolism, 2012 - cell.com
Mitochondria are intracellular powerhouses that produce ATP and carry out diverse
functions for cellular energy metabolism. Although the maintenance of an optimal …
functions for cellular energy metabolism. Although the maintenance of an optimal …
Metabolic regulation of histone post-translational modifications
Histone post-translational modifications regulate transcription and other DNA-templated
functions. This process is dynamically regulated by specific modifying enzymes whose …
functions. This process is dynamically regulated by specific modifying enzymes whose …
Axon degeneration: molecular mechanisms of a self-destruction pathway
JT Wang, ZA Medress, BA Barres - Journal of Cell Biology, 2012 - rupress.org
Axon degeneration is a characteristic event in many neurodegenerative conditions including
stroke, glaucoma, and motor neuropathies. However, the molecular pathways that regulate …
stroke, glaucoma, and motor neuropathies. However, the molecular pathways that regulate …
Location, location, location: compartmentalization of NAD+ synthesis and functions in mammalian cells
The numerous biological roles of NAD+ are organized and coordinated via its
compartmentalization within cells. The spatial and temporal partitioning of this intermediary …
compartmentalization within cells. The spatial and temporal partitioning of this intermediary …
Wallerian Degeneration, WldS, and Nmnat
MP Coleman, MR Freeman - Annual review of neuroscience, 2010 - annualreviews.org
Traditionally, researchers have believed that axons are highly dependent on their cell
bodies for long-term survival. However, recent studies point to the existence of axon …
bodies for long-term survival. However, recent studies point to the existence of axon …
Axonal degeneration during aging and its functional role in neurodegenerative disorders
Aging constitutes the main risk factor for the development of neurodegenerative diseases.
This represents a major health issue worldwide that is only expected to escalate due to the …
This represents a major health issue worldwide that is only expected to escalate due to the …
Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine …
Y Sasaki, BPS Vohra, FE Lund… - Journal of …, 2009 - Soc Neuroscience
Axonal degeneration is a hallmark of many neurological disorders. Studies in animal models
of neurodegenerative diseases indicate that axonal degeneration is an early event in the …
of neurodegenerative diseases indicate that axonal degeneration is an early event in the …
Microbial NAD metabolism: lessons from comparative genomics
SUMMARY NAD is a coenzyme for redox reactions and a substrate of NAD-consuming
enzymes, including ADP-ribose transferases, Sir2-related protein lysine deacetylases, and …
enzymes, including ADP-ribose transferases, Sir2-related protein lysine deacetylases, and …
Metabolic profiling of alternative NAD biosynthetic routes in mouse tissues
NAD plays essential redox and non-redox roles in cell biology. In mammals, its de novo and
recycling biosynthetic pathways encompass two independent branches, the “amidated” and …
recycling biosynthetic pathways encompass two independent branches, the “amidated” and …
Sarm1-dependent axon degeneration: Nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities
Axons are an essential component of the nervous system, and axon degeneration is an
early feature of many neurodegenerative disorders. The NAD+ metabolome plays an …
early feature of many neurodegenerative disorders. The NAD+ metabolome plays an …