Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

H Cao, L Duan, Y Zhang, J Cao, K Zhang - Signal transduction and …, 2021 - nature.com
Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …

Structurally dynamic hydrogels for biomedical applications: pursuing a fine balance between macroscopic stability and microscopic dynamics

K Zhang, Q Feng, Z Fang, L Gu, L Bian - Chemical Reviews, 2021 - ACS Publications
Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …

Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment

G Huang, F Li, X Zhao, Y Ma, Y Li, M Lin, G **… - Chemical …, 2017 - ACS Publications
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Engineered materials for organoid systems

MJ Kratochvil, AJ Seymour, TL Li, SP Paşca… - Nature Reviews …, 2019 - nature.com
Organoids are 3D cell culture systems that mimic some of the structural and functional
characteristics of an organ. Organoid cultures provide the opportunity to study organ-level …

Multifaceted design and emerging applications of tissue adhesives

Z Ma, G Bao, J Li - Advanced Materials, 2021 - Wiley Online Library
Tissue adhesives can form appreciable adhesion with tissues and have found clinical use in
a variety of medical settings such as wound closure, surgical sealants, regenerative …

Adaptable hydrogel networks with reversible linkages for tissue engineering

H Wang, SC Heilshorn - Advanced Materials, 2015 - Wiley Online Library
Adaptable hydrogels have recently emerged as a promising platform for three‐dimensional
(3D) cell encapsulation and culture. In conventional, covalently crosslinked hydrogels …

Click hydrogels, microgels and nanogels: Emerging platforms for drug delivery and tissue engineering

Y Jiang, J Chen, C Deng, EJ Suuronen, Z Zhong - Biomaterials, 2014 - Elsevier
Hydrogels, microgels and nanogels have emerged as versatile and viable platforms for
sustained protein release, targeted drug delivery, and tissue engineering due to excellent …

Thiol–ene “click” reactions and recent applications in polymer and materials synthesis: a first update

AB Lowe - Polymer Chemistry, 2014 - pubs.rsc.org
This contribution serves as an update to a previous review (Polym. Chem. 2010, 1, 17–36)
and highlights recent applications of thiol–ene 'click'chemistry as an efficient tool for both …

Analyte-responsive hydrogels: intelligent materials for biosensing and drug delivery

HR Culver, JR Clegg, NA Peppas - Accounts of chemical …, 2017 - ACS Publications
Conspectus Nature has mastered the art of molecular recognition. For example, using
synergistic non-covalent interactions, proteins can distinguish between molecules and bind …

Designing degradable hydrogels for orthogonal control of cell microenvironments

PM Kharkar, KL Kiick, AM Kloxin - Chemical Society Reviews, 2013 - pubs.rsc.org
Degradable and cell-compatible hydrogels can be designed to mimic the physical and
biochemical characteristics of native extracellular matrices and provide tunability of …